tumor associated macrophages

[Science Advances] Scientists demonstrated that Lyve-1+ tumor-associated macrophages supported tumor growth and identified a pivotal role for these cells in maintaining a population of perivascular mesenchymal cells that expressed α-smooth muscle actin and phenotypically resembled pericytes.

[Breast Cancer Research and Treatment] The authors examine the role of immune-activating cells, including tumour-infiltrating lymphocytes, and natural killer cells, as well as immune inhibitory cells, including T regulatory cells, and myeloid-derived suppressor cells in the breast cancer tumour microenvironment.

[OncoResponse] OncoResponse, a clinical-stage biotech company advancing immunotherapies derived from the immune systems of elite cancer responders, today announced initiation of a Phase I/II study of OR2805 in patients with advanced cancer.

[Scientific Reports] To study Hsp70 forms released from cells scientists employed the assay consisting of two affinity chromatography methods. Hsp70 content in culture medium and extracellular vesicles was measured with the aid of ELISA.

[Signal Transduction and Targeted Therapy] Scientists conducted a study by employing a pancreatic ductal adenocarcinoma (PDA)-macrophage co-culture system, an “orthotopic” PDA syngeneic mouse model, and human PDA specimens, together with macrophages derived from GARP knockout mice and multiple analytic tools including whole-genome RNA sequencing,

[Molecular Oncology] As toll-like receptor 4 (TLR4) agonists are known to regress solid tumors, scientists observed that lipopolysaccharide induced TOPORS via a TLR4–TRIF-dependent pathway, which in turn modulated the transcription of tumor suppressor scaffold/matrix attachment region-binding protein 1.