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tumor-infiltrating lymphocytes

Combine and Conquer: Manganese Synergizing Anti-TGF-β/PD-L1 Bispecific Antibody YM101 to Overcome Immunotherapy Resistance in Non-Inflamed Cancers

[Journal of Hematology & Oncology] The synergistic effect between Bivalent manganese and YM101 in vitro was determined by one-way mixed lymphocyte reaction, CFSE dilution assay, and cytokine detection.

Effects of Combinatorial Ubiquitinated Protein-Based Nanovaccine and STING Agonist in Mice With Drug-Resistant and Metastatic Breast Cancer

[Frontiers in Immunology] Investigators enriched ubiquitinated proteins (UPs) from epirubicin (EPB)-induced multi-drug-resistant cancer stem-like breast cancer cell line and tested the efficacy of α-Al2O3-UPs-4T1/EPB as therapeutic vaccine alone and in combination with the stimulator of interferon genes (STING) agonist in mice with drug-resistant and metastatic breast cancer.

Refining Patient Selection for Breast Cancer Immunotherapy: Beyond PD-L1

[ESMO Open] An intense quest is ongoing for complementary tumour- or host-related predictive biomarkers in breast immuno-oncology. Among the upcoming biomarkers, quantity, immunophenotype and spatial distribution of tumour-infiltrating lymphocytes and other tumour microenvironment cells as well as immune gene signatures emerge as most promising and are being increasingly tested in clinical trials.

Role of CXCL10 in the Progression of In Situ to Invasive Carcinoma of the Breast

[Scientific Reports] Scientists performed immune profiling to compare immune-related gene expression between ductal carcinoma in situ and invasive carcinoma of the breast using nCounter PanCancer immune Profiling Panel and found that CXCL10 was the most significant gene that had the highest difference in expression between them.

Proteomics-Derived Basal Biomarker DNA-PKcs Is Associated with Intrinsic Subtype and Long-Term Clinical Outcomes in Breast Cancer

[npj Breast Cancer] The authors evaluated DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in clinically-annotated breast cancer tissue microarrays and correlated results with immune biomarkers. They found that high expression of DNA-PKcs was significantly associated with stromal and CD8+ tumor infiltrating lymphocytes.

Integrin-αV-Mediated Activation of TGF-β Regulates Anti-tumour CD8 T Cell Immunity and Response to PD-1 Blockade

[Nature Communications] Using multiplex immunofluorescence staining in cohorts of anti-PD-1 and anti-PD-L1-treated lung cancer patients, scientists showed that decreased expression of cancer cell αV was associated with improved immunotherapy-related, progression-free survival.

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