Researchers hypothesized that tumor relapse after the selective targeting of CSCs was due to intermediate progenitor cells that maintained the tumor volume. In order to support the hypothesis, they implemented a mathematical model derived using pseudo-reactions representing the events of each cell subpopulation within the tumor.
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Cancers | Free Full-Text | A Mathematical Model of Average Dynamics in a Stem Cell Hierarchy Suggests the Combinatorial Targeting of Cancer Stem Cells and Progenitor Cells as a Potential Strategy against Tumor Growth | HTML. (n.d.). Retrieved September 16, 2020, from https://www.mdpi.com/2072-6694/12/9/2590/htm Cite
Researchers demonstrated that metabolic reprogramming induced by mitochondrial fusion was rate-limiting for immortalization of tumor-initiating cells and triggered their irreversible dedication to tumorigenesis.
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Bonnay, F., Veloso, A., Steinmann, V., Köcher, T., Abdusselamoglu, M. D., Bajaj, S., Rivelles, E., Landskron, L., Esterbauer, H., Zinzen, R. P., & Knoblich, J. A. (2020). Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.07.039 Cite
By using primary patient-derived medulloblastoma (MB) brain tumor-initiating cell lines, investigators characterized differences in the tumor-initiating capacity of Wnt, group three, and group four MB.
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Investigators aimed to identify a death-associated factor 6 (DAXX)-inducing agent to inhibit tumor initiating cells and prevent proliferation of the tumor.
[npj Breast Cancer]
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Based on the methods for isolating and identifying cancer stem cells and the functional features of long-term tumor-initiating cells (LT-TICs), the authors aimed to identify a subpopulation of LT-TICs.
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Researchers found that selective antagonists of 5-HT5A reduced the frequency of tumorsphere initiating cells residing in breast tumor cell lines and those of patient-derived xenografts that they established.
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Scientists showed that LEFTY1, a secreted inhibitor of NODAL/SMAD2 signaling, was produced by mammary progenitor cells and, concomitantly, suppresses SMAD2 and SMAD5 signaling to promote long-term proliferation of normal and malignant mammary epithelial cells.
[Cell Stem Cell]
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Zabala, M., Lobo, N. A., Antony, J., Heitink, L. S., Gulati, G. S., Lam, J., Parashurama, N., Sanchez, K., Adorno, M., Sikandar, S. S., Kuo, A. H., Qian, D., Kalisky, T., Sim, S., Li, L., Dirbas, F. M., Somlo, G., Newman, A., Quake, S. R., & Clarke, M. F. (2020). LEFTY1 Is a Dual-SMAD Inhibitor that Promotes Mammary Progenitor Growth and Tumorigenesis. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.06.017 Cite
The authors showed, using a mouse model of squamous cell carcinoma, that tumor-initiating cells play a crucial role in creating a niche microenvironment that is required for tumor progression and drug resistance.
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The authors investigated the consensus of leukemia inhibitory factor (LIF) and LIF receptor immunization on the growth of mouse mammary tumors.
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Researchers address the current knowledge regarding cancer stem cells (CSCs) with a focus on designing chemotherapeutic and bio-imaging reagents that target CSCs.
[Chemical Society Reviews]
The authors report that chemosensitivity assays using liquid biopsy-derived metastatic epithelial ovarian cancer circulating tumor cells, from 10 patients, nine with stage IIIC and one with stage IV disease, in progression after systemic chemotherapy, submitted for hypoxic isolated abdominal perfusion, were both feasible and useful in predicting response to therapy.
[International Journal of Molecular Sciences]
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