tumor initiating cells

[Science Translational Medicine] Scientists performed the basal-like breast cancers (BLBCs) tissue microarray–based immunohistochemical analysis and showed that Faciogenital Dysplasia 5 abundance was associated with poor prognosis in BLBCs.

[Cell Death & Disease] Researchers reported that expression of mucin 15 (MUC15) was downregulated in liver tumor-initiating cells, chemoresistance, and recurrent HCC samples.

[Advanced Science] Based on clinical samples, patient-derived cells, and cell lines, it was found that liver cancer cells displayed stem-like characteristics upon glutamine shortage due to maintaining the stemness of tumor initiating cells (TICs) and even promoting transformation of non-TICs into stem-like cells by glutamine starvation.

[Cell Death & Disease] Scientists depicted the mechanism of breast cancer stem cells’ (bCSCs) response to replication stress (RS) and its clinical implication, and demonstrated that bCSCs presented a limited level of RS compared with non-bCSCs in patient samples.

[Molecular Biology Reports] Researchers demonstrated that As2O3 had a remarkable inhibitory effect on tumor initiating cells of small cell lung cancer both in vitro and in vivo, and the mechanism might have involved the down-regulation of Notch pathway

[FEBS Journal] The authors discuss cancer-type specific molecular targets, context-dependent mechanisms and future directions of research in targeting EHMT1/EHMT2 for the treatment of cancer.