tumor initiating cells

[Science Translational Medicine] Scientists found that lysine-specific histone demethylase 1 (LSD1) inhibition hampered the induction of the activating transcription factor 4, the master regulator of the integrated stress response.

[Hepatology Communications] Treatment effects on tumor-initiating cells were estimated by sphere-forming capacity in vitro, tumorigenicity in vivo, and flow cytometry.

[Cell Reports] Scientists showed that Myc-driven hepatocellular carcinoma was dramatically aggravated in mice with hepatocyte-specific Ptpn11/Shp2 deletion.

[European Respiratory Review] The authors review the relevant literature in this rapidly expanding field, including results from mouse models and human studies. In addition, they present a case for club cells as cells of origin of lung adenocarcinomas that arise in smokers.

[Cancer Research] Mechanistically, ALDH1A1 decreased the intracellular pH in breast cancer cells to promote phosphorylation of TAK1, activated NFκB signaling, and increased the secretion of granulocyte macrophage colony-stimulating factor, which led to myeloid-derived suppressor cell expansion and immunosuppression.

[Cancer Research] Scientists showed follistatin-like 1 (FSTL1) expression to be closely correlated with activated fibroblasts and to be elevated in regenerative, fibrotic, and disease liver states in various mouse models. Consistently, FSTL1 lineage cells gave rise to myofibroblasts in a CCL4-induced hepatic fibrosis mouse model.