tumor initiating cells

[Bioorganic Chemistry] Investigators identified a highly specific peptidomimetic that selectively bound to the CSC subpopulation of lung cancer over the remaining cancer cells.

[Biochimie] To understand the role of the adipose-derived stem cell secretome in breast cancer cell proliferation, death, and phenotype alteration, adipose-derived stem cell-conditioned medium was used to cultivate MCF-7 and MDA-MB-231 cells.

[Cell Reports] Circular RNA stabilizing HOXC10 (cis-HOX) was robustly expressed in colorectal tumor-initiating cells (TICs). cis-HOX knockout decreased colorectal TIC numbers and impaired the self-renewal, tumorigenesis, and metastatic capacities of TICs, whereas cis-HOX overexpression drove colorectal TIC self-renewal and metastasis.

[Nature Communications] Investigators found that tumor endothelial marker 8 (TEM8) was abundantly expressed in triple-negative breast cancer and served as a marker for vasculogenic mimicry-forming breast tumor-initiating cells.

[Developmental Cell] Using a Drosophila solid-tumor model where oncogenic Notch drove tumorigenesis in a transition-zone microenvironment in the salivary gland imaginal ring, researchers found that the tumor-initiating cells normally undergo endoreplication to become polyploid.

[Biomedicine & Pharmacotherapy] A library of 17 C1-single and C1/C20-double modified salinomycin analogs was screened to identify compounds with improved activity against breast cancer stem cells.