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type I diabetes

CRISPR Therapeutics and ViaCyte, Inc. Announce First Patient Dosed in Phase I Clinical Trial of Novel Gene-Edited Cell Replacement Therapy for Treatment of Type...

[ViaCyte, Inc.] CRISPR Therapeutics and ViaCyte, Inc. announced the first patient has been dosed in the Phase I clinical trial of VCTX210 for the treatment of T1D.

PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes

[Diabetes] Scientists assessed the global protein and individual protein tyrosine phosphatases (PTP) profiles in the pancreas from early onset non-obese diabetic mice treated with an anti-CD3 monoclonal antibody and interleukin-1 receptor antagonist.

Emerging Strategies for Beta Cell Transplantation to Treat Diabetes

[Trends in Pharmacological Sciences] Beta cell replacement has emerged as an attractive therapeutic alternative to traditional exogenous insulin administration for management of type 1 diabetes.

Gastrin Producing Syngeneic Mesenchymal Stem Cells Protect Non-obese Diabetic Mice from Type 1 Diabetes

[Autoimmunity] Scientists reported the use of MSCs for the production and delivery of Gastrin, a peptide hormone that is produced by intestinal cells and fetal islets and can increase β-cell mass, to promote protection from type 1 diabetes.

Abnormal Cannabidiol Ameliorates Inflammation Preserving Pancreatic Beta Cells in Mouse Models of Experimental Type 1 Diabetes and Beta Cell Damage

[Biomedicine & Pharmacotherapy] Scientists investigated whether Abn-CBD can modulate the inflammatory response during type 1 diabetes (T1D) onset using a mouse model of T1D and of beta cell damage.

Regenerative Approaches to Preserve Pancreatic β-Cell Mass and Function in Diabetes Pathogenesis

[Endocrine] Regeneration proceedings for pancreatic β cells are promising and could improve β-cell proliferation capacity and contribute to the conservation of mature β-cell phenotypic characteristics.

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