type I diabetes

[American Journal of Chinese Medicine] Researchers investigated the role of puerarin in endoplasmic reticulum stress-associated apoptosis and explore its underlying mechanism in the mouse insulinoma cell line.

[Cell Stem Cell] Scientists enhanced subcutaneous engraftment by employing a unique vascularization strategy based on ready-made microvessels isolated from the adipose tissue.

[Nature Communications] HLA-DQ8-HIP tetramer+ T cells from the peripheral blood of a T1D patient are characterized by repeated TRBV5 usage, which matched the TCR bias of CD4+ T cells reactive to the HIP peptide isolated from the pancreatic islets of a patient with T1D.

[Nature Communications] Researchers showed that Tet2 regulated pathologic interactions between β cells and immune cells and controlled damaging inflammatory pathways.

[Journal of Molecular Medicine] Scientists showed that proteomic analyses of pancreas tissue from non-obese diabetic (NOD) mice suggested that FhHDM-1 activated the PI3K/Akt signalling pathway, which was associated with β-cell metabolism, survival and proliferation.

[Nature Reviews Drug Discovery] Scientists discuss the state of the art of stem cell differentiation and islet engineering, reflect on current and future challenges in the area and highlight the potential for cell replacement therapies, disease modelling and drug development using these cells.