Fractyl Announces FDA Breakthrough Device Designation for Revita® DMR in Insulin-Treated Type II Diabetes

Fractyl Laboratories Inc. announced that the US FDA has granted Breakthrough Device Designation for Revita® DMR in patients with insulin-treated type II diabetes (T2D).
[Fractyl Laboratories, Inc.]
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miR-335-5p Aggravates Type 2 Diabetes by Inhibiting SLC2A4 Expression

The levels of miR-335-5p and solute carrier family 2 member 4 (SLC2A4) in blood samples collected from patients with type 2 diabetes (T2D blood samples) and pancreatic cell lines were measured by Real Time quantitative PCR (RT-qPCR).
[Biochemical and Biophysical Research Communications]
miR-335-5p aggravates type 2 diabetes by inhibiting SLC2A4 expression. (2021). Biochemical and Biophysical Research Communications, 558, 71–78. https://doi.org/10.1016/j.bbrc.2021.04.011 Cite
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VPS39-Deficiency Observed in Type 2 Diabetes Impairs Muscle Stem Cell Differentiation via Altered Autophagy and Epigenetics

Scientists discovered a pathway connecting VPS39-deficiency in human myoblasts to impaired autophagy, abnormal epigenetic reprogramming, dysregulation of myogenic regulators, and perturbed differentiation.
[Nature Communications]
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CRISPR-Based Genome Editing in Primary Human Pancreatic Islet Cells

Scientists demonstrated successful genome editing in primary human islets using clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9).
[Nature Communications]
Bevacqua, R. J., Dai, X., Lam, J. Y., Gu, X., Friedlander, M. S. H., Tellez, K., Miguel-Escalada, I., Bonàs-Guarch, S., Atla, G., Zhao, W., Kim, S. H., Dominguez, A. A., Qi, L. S., Ferrer, J., MacDonald, P. E., & Kim, S. K. (2021). CRISPR-based genome editing in primary human pancreatic islet cells. Nature Communications, 12(1), 2397. https://doi.org/10.1038/s41467-021-22651-w Cite
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Pancreastatin Induces Islet Amyloid Peptide Aggregation in the Pancreas, Liver, and Skeletal Muscle: An Implication for Type 2 Diabetes

Scientists investigated whether Pancreastatin induced islet amyloid peptide aggregation in the pancreas, liver, and skeletal muscles.
[International Journal of Biological Macromolecules]
Pancreastatin induces islet amyloid peptide aggregation in the pancreas, liver, and skeletal muscle: An implication for type 2 diabetes. (2021). International Journal of Biological Macromolecules, 182, 760–771. https://doi.org/10.1016/j.ijbiomac.2021.04.064 Cite
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Single-Cell Chromatin Accessibility Identifies Pancreatic Islet Cell Type-and State-Specific Regulatory Programs of Diabetes Risk

Researchers observed state-specific enrichment of fasting glucose and type 2 diabetes genome-wide association studies for beta cells and enrichment for other endocrine cell types.
[Nature Genetics]
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Effects of Diet, BMP-2 Treatment, and Femoral Skeletal Injury on Endothelial Cells Derived from the Ipsilateral and Contralateral Limbs

Researchers examined the effects of bone morphogenetic protein‐2 administered locally at the time of femoral segmental bone defect surgery, and its angiogenic impacts on endothelial cellsisolated from the ipsilateral or contralateral tibia in type 2 diabetes mice.
[Journal of Orthopaedic Research]
Dadwal, U. C., Staut, C. de A., Tewari, N. P., Awosanya, O. D., Mendenhall, S. K., Valuch, C. R., Nagaraj, R. U., Blosser, R. J., Li, J., & Kacena, M. A. (n.d.). Effects of diet, BMP-2 treatment, and femoral skeletal injury on endothelial cells derived from the ipsilateral and contralateral limbs. Journal of Orthopaedic Research, n/a(n/a). https://doi.org/https://doi.org/10.1002/jor.25033 Cite
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Oramed Reaches 25% Randomization in World’s First Phase III Oral Insulin Study Conducted under FDA Approved Protocol

Oramed Pharmaceuticals, Inc. announced that it has enrolled and randomized 25% of the 675 patients planned for its Phase III ORA-D-013-1 study of its oral insulin capsule ORMD-0801 for the treatment of type 2 diabetes.
[Oramed Pharmaceuticals, Inc.]
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BCDIN3D RNA Methyltransferase Stimulates Aldolase C Expression and Glycolysis through Let-7 MicroRNA in Breast Cancer Cells

In order to uncover metabolic pathways regulated by BCDIN3D in cancer, we performed an unbiased analysis of the metabolome, transcriptome, and proteome of breast cancer cells depleted for BCDIN3D.
[Oncogene]
BCDIN3D RNA methyltransferase stimulates Aldolase C expression and glycolysis through let-7 microRNA in breast cancer cells | Oncogene. (n.d.). Retrieved March 4, 2021, from https://www.nature.com/articles/s41388-021-01702-y Cite
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Pancreatic Progenitor Epigenome Maps Prioritize Type 2 Diabetes Risk Genes with Roles in Development

The authors investigated contributions of regulatory programs active during pancreatic development to type 2 diabetes risk.
[eLife]
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Amylin Deposition Activates HIF1α and 6-Phosphofructo-2-Kinase/Fructose-2, 6-Biphosphatase 3 (PFKFB3) Signaling in Failing Hearts of Non-Human Primates

Researchers demonstrated that in non-human primates, amylin deposition in heart failure contributed to cardiac dysfunction via activation of HIF1α and PFKFB3 signaling.
[Communications Biology]
Liu, M., Li, N., Qu, C., Gao, Y., Wu, L., & Hu, L. G. (2021). Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates. Communications Biology, 4(1), 1–17. https://doi.org/10.1038/s42003-021-01676-3 Cite
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