type II diabetes

[Cardiovascular Diabetology] Scientists analyzed endothelial microparticles with apoptotic characteristics and assessed the angiogenic contents of microparticles in the blood of patients with type 2 diabetes according to the presence of coronary artery disease.

[Nature Communications] Scientists showed that the death receptor TMEM219 was expressed on pancreatic beta cells and that signaling through its ligand insulin-like growth factor binding protein 3 (IGFBP3) led to beta cell loss and dysfunction.

[Cell Metabolism] Investigators examined α cells from human donors and mice using electrophysiological, transcriptomic, and computational approaches.

[Journal of Clinical Endocrinology & Metabolism] Researchers leveraged global transcriptome- and accompanying epigenome-wide changes in 48 umbilical cord blood (UCB) from newborns of early pregnancy (EP)-anemic Tanzanian mothers and 50 controls to identify differentially expressed genes in UCB exposed to maternal EP-anemia.

[Journal of Biological Chemistry] Researchers reported that intra-islet glucagon secreted from α-cells signals through β-cell glucagon and GLP-1 receptors, thereby conferring to rat islets their competence to exhibit first phase glucose-stimulated insulin secretion.

[npj Parkinson's Disease] To detect potential effects of different glucose levels on gene expression, by RNA-seq researchers analyzed the transcriptome of dermal fibroblasts from idiopathic Parkinson’s disease (PD) patients, LRRK2-associated PD patients, and healthy controls, cultured at two different glucose concentrations.