type II diabetes

[Endocrine] Regeneration proceedings for pancreatic β cells are promising and could improve β-cell proliferation capacity and contribute to the conservation of mature β-cell phenotypic characteristics.

[Science Signaling] Researchers found that primary human adipocytes shed extracellular vesicles, specifically exosomes, that induced the expression of genes associated with epithelial-to-mesenchymal transition and cancer stem–like cell traits in cocultured breast cancer cell lines.

[Oramed Pharmaceuticals, Inc.] Oramed Pharmaceuticals Inc. announced that it has enrolled and randomized over 75% of the 675 patients planned for its Phase III ORA-D-013-1 study of its oral insulin capsule ORMD-0801 for the treatment of type 2 diabetes.

[Diabetes] Researchers reported increased expression of miR-200c in islets from type 2 diabetes as compared with non-diabetic donors and displayed results showing reduced glucose-stimulated insulin secretion in EndoC-βH1 cells overexpressing miR-200c.

[Cell Reports] Investigators analyzed over two million cells from 16 pancreata obtained from donors with type 2 diabetes and 13 pancreata from age-similar non-diabetic controls.

[Cell Reports] Scientists created the translational human pancreatic islet genotype tissue-expression resource (TIGER), aggregating over 500 human islet genomic datasets from five cohorts in the Horizon 2020 consortium T2DSystems.