type II diabetes

[Journal of Nutritional Biochemistry] Researchers explored the underlying mechanisms of type 2 diabetes prevention by vitamin D, concentrating on pancreatic iron deposition reported recently.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators identified that coronavirus induced an increased Mφ-mediated inflammatory response due to a coronavirus-induced decrease in the histone methyltransferase, SETDB2.

[Nature Communications] Using massively parallel reporter assays, scientists tested the cis-regulatory effects of single nucleotide polymorphisms associated with type 2 diabetes (T2D) and altered in vivo islet chromatin accessibility in MIN6 β cells under steady state and pathophysiologic endoplasmic reticulum stress conditions.

[Scientific Reports] Investigators showed that intramuscular injection of placental (P)-MSCs homed more towards the visceral site, restored HOMA-IR and glucose homeostasis in the WNIN/GR-Ob rats. P-MSC therapy was effective in re-establishing the dysregulated cytokines.

[Journal of Molecular Medicine] Scientists showed that proteomic analyses of pancreas tissue from non-obese diabetic (NOD) mice suggested that FhHDM-1 activated the PI3K/Akt signalling pathway, which was associated with β-cell metabolism, survival and proliferation.

[Nature Reviews Drug Discovery] Scientists discuss the state of the art of stem cell differentiation and islet engineering, reflect on current and future challenges in the area and highlight the potential for cell replacement therapies, disease modelling and drug development using these cells.