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Peptide-Functionalized Electrospun Meshes for the Physiological Cultivation of Pulmonary Alveolar Capillary Barrier Models in a 3D-Printed Micro-Bioreactor

[ACS Biomaterials Science & Engineering] An in vitro pulmonary alveolar capillary barrier model was developed that closely mimics physiological functions by combining a synthetic biofunctionalized nanofibrous membrane system with a novel three-dimensional (3D)-printed bioreactor.

Schisandrin a Regulates the Nrf2 Signaling Pathway and Inhibits NLRP3 Inflammasome Activation To Interfere With Pyroptosis in a Mouse Model of COPD

[European Journal Of Medical Research] Researchers studied the pharmacological effect of Schisandrin A (SchA) on airway inflammation induced by cigarette smoke and explored the therapeutic mechanism of SchA in COPD model mice.

UHRF1 Is a Mediator of KRAS Driven Oncogenesis in Lung Adenocarcinoma

[Nature Communications] To identify KRAS-specific vulnerabilities in lung cancer, scientists performed RNAi screens in primary spheroids derived from a Kras mutant mouse lung cancer model and discovered an epigenetic regulator Ubiquitin-like containing PHD and RING finger domains 1 (UHRF1).

MLK4 Promotes Glucose Metabolism in Lung Adenocarcinoma Through CREB-Mediated Activation of Phosphoenolpyruvate Carboxykinase and Is Regulated by KLF5

[Oncogenesis] Investigators showed that MLK4 was overexpressed in a significant subset of lung adenocarcinoma, associated with a worse prognosis, and exerted an oncogenic function in vitro and in vivo.

The Role of TOP2A in Immunotherapy and Vasculogenic Mimicry in Non-Small Cell Lung Cancer and Its Potential Mechanism

[Scientific Reports] Scientists investigated the role of type IIA topoisomerase (TOP2A) in proliferation, skeleton regulation, motility, and Vasculogenic mimicry production in NSCLC and its mechanisms by using bioinformatics tools and molecular biology experiments.

Directed Neural Stem Cells Differentiation via Signal Communication With Ni-Zn Micromotors

[Advanced Materials] Through an electric-chemical field, bioelectrical signal exchange and communication with endogenous neural stem cells were allowed, thus allowing for regulated proliferation and directed neuron differentiation in vivo.

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