Publication

[Molecular Carcinogenesis] In a mouse xenograft co-injection model, investigators observed that ovulatory follicular fluid co-injection induced tumorigenesis of serous tubal intraepithelial carcinoma-mimicking cells, FE25.

[Nature Communications] Investigators showed that brain endothelial cells process and cross-present antigen, leading to effector CD8+ T cell differentiation. Under physiological flow in vitro, endothelial antigen presentation prevented CD8+ T cell crawling and diapedesis resulting in brain endothelial cell apoptosis and blood-brain barrier breakdown.

[eLife] Scientists investigated WDR62 function in corticogenesis through the analysis of a C-terminal truncating mutation. They generated 2D and 3D models of human neurodevelopment, including neuroepithelial stem cells, cerebro-cortical progenitors, terminally differentiated neurons, and cerebral organoids.

[Acta Pharmacologica Sinica] Researchers investigated the role of SIRT1 in deoxypodophyllotoxin (DPT)-induced human glioma cell parthanatos. They showed that DPT activated both polymerase 1 and SIRT1, and induced parthanatos in U87 and U251 glioma cells.

[Food And Chemical Toxicology] Scientists evaluated the effect of astaxanthin in preventing rotenone-induced toxicity of SK-N-SH human neuroblastoma cells in an in vitro model of experimental Parkinsonism.

[Journal Of Ethnopharmacology] Investigators evaluated the anti-inflammatory effect and elucidated underlying molecular mechanisms of saikosaponins B2 in lipopolysaccharide-induced primary microglia and chronic unpredictable mild stress-induced mice model of depression.