Publication

[Stem Cells International] SET domain-containing protein 4 (SETD4)-positive cells were identified as quiescent lung cancer stem cells, since they expressed high levels of ALDH1 and CD133 and low levels of Ki67.

[Cancer Research] Investigators identified cold sensitivity at 4°C, commonly used for sample storage, as a novel vulnerability that selectively killed acute myeloid leukemic stem cells with active fatty acid oxidation-supported mitochondrial oxidative phosphorylation while sparing normal hematopoietic stem cells.

[Cancer Science] Researchers found that AML-mesenchymal stem cellss induced a significant mesenchymal-like morphology in drug-resistant AML cells, but it was scarce in parental AML cells.

[BMC Complementary Medicine And Therapies] CSC-rich populations of A549 cells were generated, and CSC markers, and Akt signaling were determined by Western blot analysis and immunofluorescence.

[Biochemical And Biophysical Research Communications] To monitor asymmetric cell division of ALDH1A3-positive pancreatic ductal adenocarcinoma (PDAC) CSCs, researchers established stable Panc-1 PDAC clones expressing ALDH1A3-turboGFP.

[Oral Oncology] Therapeutic efficacy of a small molecule inhibitor of Bmi-1 and/or Cisplatin on adenoid cystic carcinoma (ACC) stemness was evaluated in immunodeficient mice harboring PDX ACC tumors, and in human ACC cell-lines, or low passage primary human ACC cells.