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Combined Lineage Tracing and scRNA-Seq Reveals Unexpected First Heart Field Predominance of Human iPSC Differentiation

[eLife] The authors described the development of a TBX5/MYL2 lineage tracing reporter system that allows for the identification of FHF- progenitors and their descendants including left ventricular cardiomyocytes.

Effects of Acute Low-Moderate Dose Ionizing Radiation to Human Brain Organoids

[PLOS One] The authors generated brain/cerebral organoids from human iPSCs to study the radiosensitivity of human brain cells, including neurons, astrocytes, and oligodendrocytes.

Engineered Extracellular Matrices Facilitate Brain Organoids from Human Pluripotent Stem Cells

[Annals Of Clinical And Translational Neurology] Investigators generated brain organoids using engineered extracellular matrix comprised of human fibrillar fibronectin supported by a highly porous polymer scaffold.

A T Cell-Engaging Tumor Organoid Platform for Pancreatic Cancer Immunotherapy

[Advanced Science] To facilitate drug discovery combating immunosuppressive pancreatic ductal adenocarcinoma, a high-throughput drug screen platform was established with the newly developed T cell-incorporated pancreatic tumor organoid model.

Fabrication of Oxygen-Carrying Microparticles Functionalized with Liver ECM-Proteins to Improve Phenotypic Three-Dimensional In Vitro Liver Assembly, Function, and Responses

[Biotechnology And Bioengineering] Hepatocytes and hepatic stellate cells exhibited more pronounced phenotypic arrangements when cocultured with laminin-511 and 521 modified chitosan microparticles.

Portable and Integrated Microfluidic Flow Control System Using Off-the-Shelf Components Towards Organs-on-Chip Applications

[Biomedical Microdevices] 3D printing was used to fabricate a custom-designed platform box for mounting the chosen smallest footprint components. A demonstrator system was realized for lung-on-a-chip experiments.

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