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Publication
Cancer Stem Cell News
Combined Lineage Tracing and scRNA-Seq Reveals Unexpected First Heart Field Predominance of Human iPSC Differentiation
[eLife] The authors described the development of a TBX5/MYL2 lineage tracing reporter system that allows for the identification of FHF- progenitors and their descendants including left ventricular cardiomyocytes.
Neural Cell News
Effects of Acute Low-Moderate Dose Ionizing Radiation to Human Brain Organoids
[PLOS One] The authors generated brain/cerebral organoids from human iPSCs to study the radiosensitivity of human brain cells, including neurons, astrocytes, and oligodendrocytes.
Extracellular Matrix News
Engineered Extracellular Matrices Facilitate Brain Organoids from Human Pluripotent Stem Cells
[Annals Of Clinical And Translational Neurology] Investigators generated brain organoids using engineered extracellular matrix comprised of human fibrillar fibronectin supported by a highly porous polymer scaffold.
Immune Regulation News
A T Cell-Engaging Tumor Organoid Platform for Pancreatic Cancer Immunotherapy
[Advanced Science] To facilitate drug discovery combating immunosuppressive pancreatic ductal adenocarcinoma, a high-throughput drug screen platform was established with the newly developed T cell-incorporated pancreatic tumor organoid model.
Hepatic Cell News
Fabrication of Oxygen-Carrying Microparticles Functionalized with Liver ECM-Proteins to Improve Phenotypic Three-Dimensional In Vitro Liver Assembly, Function, and Responses
[Biotechnology And Bioengineering] Hepatocytes and hepatic stellate cells exhibited more pronounced phenotypic arrangements when cocultured with laminin-511 and 521 modified chitosan microparticles.
Newsletters
Portable and Integrated Microfluidic Flow Control System Using Off-the-Shelf Components Towards Organs-on-Chip Applications
[Biomedical Microdevices] 3D printing was used to fabricate a custom-designed platform box for mounting the chosen smallest footprint components. A demonstrator system was realized for lung-on-a-chip experiments.