Massively Parallel Reporter Assays of Melanoma Risk Variants Identify MX2 as a Gene Promoting Melanoma

Researchers showed that melanocyte-specific expression of human MX2 in a zebrafish model demonstrated accelerated melanoma formation in a BRAFV600E background.
[Nature Communications]
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Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness

Using a cancer cell model to trigger non-lethal caspase activation, the authors found that melanoma cancer cells undergoing failed apoptosis have a particular transcriptomic signature associated with focal adhesions, transendothelial migration, and modifications of the actin cytoskeleton.
[Cell Reports]
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Intracellular Virus Sensor MDA5 Exacerbates Vitiligo by Inducing the Secretion of Chemokines in Keratinocytes under Virus Invasion

Researchers clarified that virus invasion significantly activated MDA5 and further potentiated the keratinocyte-derived CXCL10 and CXCL16 which are the two vital chemokines for the cutaneous infiltration of CD8+ T cells in vitiligo.
[Cell Death & Disease]
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POU4F1 Promotes the Resistance of Melanoma to BRAF Inhibitors through MEK/ERK Pathway Activation and MITF Up-Regulation

The authors report that over-expressed POU4F1 contributed to the acquired resistance of melanoma cells to Vemurafenib. POU4F1 also promoted the activation of ERK signaling pathway via transcriptional regulation on MEK expression.
[Cell Death & Disease]
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Topical Application of Endothelin Receptor A Antagonist Attenuates Imiquimod-Induced Psoriasiform Skin Inflammation

Researchers investigated the effects of endothelin-1 (ET-1) receptor antagonist on imiquimod-induced psoriasiform dermatitis in a mouse model and found that ET-1 and endothelin A receptor axis played an important role in the pathogenesis of psoriasis.
[Scientific Reports]
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Percutaneous Absorption of Resveratrol and Its Oligomers to Relieve Psoriasiform Lesions: In Silico, In Vitro and In Vivo Evaluations

Scientists investigated the antipsoriatic activity of topical administration of resveratrol oligomers and explored the effect of the number of resveratrol subunits on skin absorption to establish the structure-permeation relationship.
[International Journal of Pharmaceutics]
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GDNF Promotes Hair Formation and Cutaneous Wound Healing by Targeting Bulge Stem Cells

Using a Gfra1 (glial-cell-derived neurotrophic factor (GDNF) family receptor alpha 1) knock-in reporter mouse line, GDNF signaling was found to occur within hair bulge stem cells during the initiation of the hair cycle and early stages of hair formation after depilation.
[NPJ Regenerative Medicine]
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Induction of IRAK-M in Melanoma Induces Caspase-3 Dependent Apoptosis by Reducing TRAF6 and Calpastatin Levels

Scientists showed that IRAK-M, a negative regulator of MyD88 signaling, was deficient or low in melanoma and expression levels correlated with patient survival. Inducing IRAK-M expression using genetic approaches or epigenetic modifiers initiated apoptosis by prompting its interaction with TRAF6.
[Communications Biology]
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A Self-Sustaining Endocytic-Based Loop Promotes Breast Cancer Plasticity Leading to Aggressiveness and Pro-Metastatic Behavior

Investigators report that Epsin 3 is an oncogene with prognostic and therapeutic relevance in breast cancer.
[Nature Communications]
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Risk Score to Predict Event-Free Survival after Hematopoietic Cell Transplant for Sickle Cell Disease

Investigators developed a risk score to predict event-free survival after allogeneic hematopoietic cell transplantation for sickle cell disease.
[Blood]
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Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations

The authors established an efficient CRISPR/Cas9-based mixed lineage leukemia rearrangements model in hematopoietic stem and progenitor cells (HSPCs) derived from human cord blood (huCB) and faithfully mimicked the underlying biology of the disease. They applied this model to HSPCs from adult bone marrow to investigate the impact of the cell of origin and fusion partner on disease development.
[Cancers]
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