Publication

[Cancer] Even in the absence of a matched sibling donor, outcomes of allogeneic hematopoietic cell transplantation in second complete remission for acute myeloid leukemia have significantly improved over time, with most favorable outcomes achieved with matched unrelated donors.

[Scientific Reports] Researchers studied whether epidermal growth factor receptor (EGFR) was a substrate of prostasin (PRSS8) in pancreatic β-cells and that PRSS8 modulated insulin secretion via EGF–EGFR signaling.

[Scientific Reports] Scientists developed a protocol to harvest and aggregate human pluripotent stem cells-derived pancreatic progenitors generated using a commercially available kit into near uniform spheroids and to further differentiate the cells toward an endocrine cell fate in suspension culture.

[Oncology Reports] Using an in vitro coculture model, it was shown that adipocytes promoted tumor progression, and an intricate metabolic network between pancreatic cancer cells and adipocytes was identified and elucidated.

[Journal Of Clinical Investigation] Using human and murine homologous recombination (HR)-deficient PDAC models, scientists found that polymerase theta knockdown was synthetically lethal in combination with mutations in HR genes such as BRCA1 and BRCA2 and the DNA damage repair gene

[Cell Death & Differentiation] Researchers reported iASPP, an inhibitor of p53, as a paradoxical suppressor of inflammation and oncogenic KRASG12D-driven pancreatic cancer tumorigenesis.