Publication

[Food & Function] Investigators examined the potential therapeutic benefits of fenugreek in treating endothelila dysfunction and investigated the underlying mechanism associated with its effects.

[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] Researchers employed NY0123 to explore the anti-angiogenic biological role of exchange protein directly activated by cAMP 1 (EPAC1) in vitro and in vivo through vascular endothelial cells, rat aortic ring, Matrigel plug, and chick embryo chorioallantoic membrane and yolk sac membrane assays.

[Acta Biomaterialia] Scientists applied unidirectional shear stress to promote hiPSCs differentiation into valvular endothelial-like (VELs) cells. They found that Piezo1 served as a crucial mechanosensor for the differentiation and maturation of VELs.

[Leukemia] Scientists showed that max-gene-associated regulated multiple pro-proliferative pathways in hematopoietic cells and cooperated with the RUNX1::RUNX1T1 fusion oncoprotein to enhance leukemogenesis.

[Nature Immunology] Using reverse mutagenesis, the authors found that a phenylalanine-to-serine mutation at position 375 in the spike protein of Omicron to revert it to the sequence found in Delta and other ancestral strains significantly enhanced the immunogenicity of Omicron vaccines.

[NPJ Vaccines] Researchers evaluated the immunogenicity and efficacy of different rationally designed lipid and polymeric-based nanoparticle prototypes against SARS-CoV-2 infection.