Publication

[Journal Of Leukocyte Biology] Investigators found that CD38’s extracellular glycohydrolase activity restricts metabolic reprogramming after TCR-engaging stimulation in Jurkat T CD4 cells, together with functional responses, while reducing intracellular NAD and NMN concentrations.

[BMC Medicine] Scientists evaluated antibody responses to SARS-CoV-2 spike and nucleocapsid antigens from Wuhan and variants of concern by Luminex and their role in preventing breakthrough infections 1 year after a third dose of mRNA vaccination, in a cohort of health care workers followed since the pandemic onset in Spain.

[Cellular And Molecular Life Sciences] Researchers characterized the function of lipid droplets and adipose triglyceride lipase-induced lipolysis in the regulation of endothelial function.

[Cytoskeleton] During the differentiation time course, researchers harvested cells on days 0, 5, 10, 15, and 20 to analyze for various sarcomeric tropomyosin (TPM) transcripts by qRT-PCR and for sarcomeric TPM proteins using two-dimensional Western blot with sarcomeric TPM-specific CH1 monoclonal antibody followed by mass spectra analyses.

[Mobile DNA] Investigators used Moloney murine leukemia virus (MLV) to explore the role of Smarcad1 in retroviral silencing in ESCs. They showed that Smarcad1 was immediately recruited to the MLV provirus.

[Molecular Neurodegeneration] Using ex vivo confocal microscopy, scientists analyzed microglial dynamic behaviors in the entorhinal cortex and hippocampus CA1 of 6-, 12-, and 21-month-old mice APOE3 or APOE4 knock-in mice expressing GFP under the CX3CR1 promoter.