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Age-Dependent Loss of HAPLN1 Erodes Vascular Integrity via Indirect Upregulation of Endothelial ICAM1 in Melanoma

[Nature Aging] Investigators showed that HAPLN1 in the dermal extracellular matrix was sufficient to maintain the integrity of melanoma-associated blood vessels, as indicated by increased collagen and VE-cadherin expression.

Cell Morphology Best Predicts Tumorigenicity and Metastasis In Vivo across Multiple TNBC Cell Lines of Different Metastatic Potential

[Breast Cancer Research] Investigators sought to classify each breast cancer cell line as poorly or highly metastatic by characterizing tumor growth and metastasis in a murine model of six commonly used human triple-negative breast cancer xenografts, as well as determine which in vitro assays commonly used to study cell motility best predict in vivo metastasis.

MicroRNA-561-3p Indirectly Regulates the PD-L1 Expression by Targeting ZEB1, HIF1A, and MYC Genes in Breast Cancer

[Scientific Reports] Researchers investigated the inhibitory effect of microRNA-561-3p on ZEB1, HIF1A, and MYC expression as oncogenes that have the most impact on programmed death ligand 1 (PD-L1) overexpression and cellular processes such as proliferation, apoptosis, and cell cycle in breast cancer cell lines

Myb Overexpression Synergizes with the Loss of Pten and Is a Dependency Factor and Therapeutic Target in T-cell Lymphoblastic Leukemia

[Hemasphere] Researchers found that an increased copy number of MYB was associated with higher MYB expression levels, and might be associated with inferior event-free survival of pediatric T-lineage acute lymphoblastic leukemia patients.

Spatial Single Cell Profiling Using Imaging Mass Cytometry – Inflammatory Versus Penetrating Crohn’s Disease

[Journal Of Crohns And Colitis] Investigators compared the immune-cell compartment of Crohn's disease (CD) fistula to inflammatory CD colitis using imaging mass cytometry and immunofluorescence.

Changes of Mycobacterium tuberculosis Specific Antigen-Stimulated CD27−CD38+IFN-γ+CD4+ T Cells Before and After Anti-tuberculosis Treatment

[European Journal Of Medical Research] Scientists investigated whether the expression of CD27CD38+ in interferon (IFN)-γ+CD4+ T cells stimulated by the specific antigen early secreted antigenic target-6/culture filter protein-10 could be a potential new therapeutic evaluation indicator for anti-tuberculosis treatment.

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