Publication

[Nature Communications] Investigators observed that approximately 1–5% of CD4+ T cells from the blood of people living with HIV-1 exhibited over-duplicated centrioles, suggesting that centrosome amplification underlies the development of HIV-1-associated cancers by driving aneuploidy.

[Journal Of Experimental Medicine] Scientists identified neutrophils as an important source of IL-26 and point to IL-26 as the key link between neutrophils and a self-sustaining autoinflammation loop in pustular psoriasis.

[Communications Biology] Investigators discovered an anti-human IL-2 antibody and engineer a covalently-linked single-agent fusion of human IL-2 and its antibody that selectively expands Treg cells and exhibits superior disease control activity in animal models of ulcerative colitis and systemic lupus erythematosus, with proper safety profile and good developability.

[Nature Communications] Scientists identified Mi-2β as a key melanoma-intrinsic effector regulating the adaptive anti-tumor immune response. Studies in genetically engineered mouse melanoma models indicated that loss of Mi-2β rescues the immune response to immunotherapy in vivo.

[Cancer Cell International] Researchers explored the expression and functional significance of NDUFAF6 in breast cancer using various databases and experimental models.

[Blood] Investigators conducted studies using a novel mouse model and clinical correlative analysis to assess whether T cell help contributed to rituximab-mediated nature killer cell antibody-dependent cellular cytotoxicity in the tumor microenvironment in vivo.