Publication

[EMBO Molecular Medicine] In a B-lymphoid cell line, ectopic MYC activity and treatment with IACS-010759 added up to induce oxidative stress, with consequent depletion of reduced glutathione and lethal disruption of redox homeostasis.

[Nature] In a phase I trial of adjuvant autogene cevumeran, an individualized neoantigen vaccine based on uridine mRNA–lipoplex nanoparticles, the authors synthesized mRNA neoantigen vaccines in real time from surgically resected pancreatic ductal adenocarcinoma tumors.

[Cellular & Molecular Immunology] Researchers performed single-cell RNA-seq analysis of matched CD57+ CD4+ T cells from blood and tonsil samples.

[Molecular Therapy] Investigators engineered a chimeric engulfment receptor, (CER)-1236, that combined the extracellular domain of TIM-4, a phagocytic receptor recognizing the 'eat me' signal phosphatidylserine, with intracellular signaling domains (TLR2/TIR, CD28, and CD3ζ) to enhance both TIM-4-mediated phagocytosis and T-cell cytotoxic function.

[Cell Reports Medicine] In vitro, MHV370 inhibited Toll-like receptors (TLR)7/8-dependent production of cytokines in human and mouse cells, notably interferon-α, a clinically validated driver of autoimmune diseases.

[Cell Reports Medicine] By single-cell RNA sequencing of 13 treatment-naive hepatoblastoma patients, scientists discovered an immune landscape characterized by aberrant accumulation of erythroblastic islands, formed by VCAM1+ macrophages and erythroid cells.