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Low Glucose Induced Alzheimer’s Disease-Like Biochemical Changes in Human Induced Pluripotent Stem Cell-Derived Neurons Is Due to Dysregulated O-GlcNAcylation

[Alzheimers & Dementia] Investigators revealed that dysregulated O-GlcNAc, in part through mitochondrial dysfunction, caused the onset of sporadic Alzheimer's disease (sAD)-like changes. They demonstrated the therapeutic potential of inhibiting O-GlcNAcase in alleviating AD-like biochemical changes.

Stalled Oligodendrocyte Differentiation in IDH-Mutant Gliomas

[Genome Medicine] Scientists showed that despite differences in clinical manifestation and genomic alterations, all isocitrate dehydrogenase-mutant gliomas resembled early stages of oligodendrocyte lineage and are stalled in oligodendrocyte differentiation due to blocked myelination program.

Upregulation of KLK8 Contributes to CUMS-Induced Hippocampal Neuronal Apoptosis by Cleaving NCAM1

[Cell Death & Disease] Researchers explored the potential function of tissue kallikrein-related peptidase 8 (KLK8) in hippocampal neuronal cell apoptosis associated with depressive disorders in rodent models of chronic unpredictable mild stress (CUMS)-induced depression.

Dedifferentiation-Derived Neural Stem Cells Exhibit Perturbed Temporal Progression

[EMBO Reports] Scientists showed that ectopic NSCs induced via bHLH transcription factor Deadpan expression failed to undergo appropriate temporal progression by constantly expressing mid-temporal transcription factor, Sloppy-paired 1/2.

Neuronopathic Gaucher Disease Models Reveal Defects in Cell Growth Promoted by Hippo Pathway Activation

[Communications Biology] Using a combination of Drosophila dGBA1b loss-of-function models and Gaucher disease (GD) patient-derived induced pluripotent stem cells differentiated towards neuronal precursors and mature neurons we showed that different GD- tissues and neuronal cells display an impairment of growth mechanisms with an increased cell death and reduced proliferation.

Spike-Timing-Dependent Plasticity Alters Electrosensory Neuron Synaptic Strength In Vitro, but Does Not Consistently Predict Changes in Sensory Tuning In Vivo

[Journal Of Nephrology] Using whole-cell intracellular recordings in awake, behaving fish, scientists paired sensory stimulation with postsynaptic spiking using the same delays. They found that Hebbian spike-timing-dependent plasticity predictably altered sensory tuning in vitro and is mediated by NMDA receptors.

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