Publication

[iScience] Investigators showed that endothelial cell senescence played a negative role in pulmonary hypertension via juxtacrine interaction with smooth muscle cells.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] By treating primary human hepatocytes with the monounsaturated fatty acid oleate, researchers showed that lipid droplets were intracellular mechanical stressors with similar effects to tissue stiffening, including nuclear deformation, chromatin condensation, and impaired hepatocyte function.

[Cell Reports] In the dimethylnitrosamine-induced HCC mouse model, hepatocyte-specific depletion of Ppancreatic progenitor cell differentiation and proliferation factor (Ppdpf) promoted hepatocarcinogenesis, and reintroduction of PPDPF into liver-specific Ppdpf knockout mice inhibits the accelerated HCC development.

[Cell Death & Disease] Investigators extracted data from TGCA database and validated RNF2 expression in our own cohort, which revealed that RNF2 was highly expressed in HCC and was associated with malignant characteristics and poor prognosis of HCC.

[Carcinogenesis] Researchers discovered the inhibitory effect of SIAH1 on HCC cell migration and invasion, which was related with regulating EMT. Molecularly, a yeast two-hybrid experiment indicated that CTR9 was a potential interacting protein of SIAH1, which was further verified by co-immunoprecipitation (co-IP) assays.

[Nature Communications] Investigators reported that, similar to interphase, mitotic cells could employ integrins to initiate adhesion to the ECM in a kindlin- and talin-dependent manner.