Publication

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators showed that extracellular vesicle (EV)+ cell abundance increased during viral infection and that EVs preferentially bound to activated, but not naive, CD8+ T cells.

[iScience] Scientists generated a panel of 17 human cell lines overexpressing SARS-CoV-2 entry factors and tested their ability to support viral infection.

[Cell Reports Physical Science] Researchers investigated the effect of an evolving spike positive charge in SARS-CoV-2 variants and subsequent interactions with heparan sulfate and the ACE2 in the glycocalyx.

[Cell Reports Medicine] The authors described a BG505 SOSIP trimer, termed GT1.2, to optimize binding to gl-CH31, the unmutated common precursor of the CH30-34 broadly neutralizing antibody lineage that acquired a large CDRH1 insertion.

[Nature Communications] By screening a library of enterohemorrhagic Escherichia coli mutants, scientists uncovered EhaF, an uncharacterized protein, as an inhibitor of innate immune responses including type I interferons.

[Cell Reports] Investigators characterized mouse PYHIN IFI207, which they found was not involved in DNA sensing but rather was required for cytokine promoter induction in macrophages.