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Hierarchically Assembled Nanofiber Scaffold Guides Long Bone Regeneration by Promoting Osteogenic/Chondrogenic Differentiation of Endogenous Mesenchymal Stem Cells

[Small] A three-dimensional vertically aligned nanofiber scaffold (VAS) was developed with long channels and large pore size. The pore of VAS toward the bone marrow cavity after transplantation enabled the scaffolds to recruit bone marrow MSCs from the bone marrow cavity to the defect area. In vivo, it is found that VAS can significantly shorten gap distance and promote new bone formation compared to the control and collagen groups after 4 and 8 weeks of implantation.

Sequential Gene Expression Analysis of Myelodysplastic Syndrome Transformation Identifies HOXB3 and HOXB7 As the Novel Targets for Mesenchymal Cells in Disease

[BMC Cancer] Researchers described sequential molecular changes and identified biomarkers in MSC of myelodysplastic syndrome (MDS) transformation. MDS-MSC was further isolated and cultured in vitro to determine the potential diagnostic and prognostic value of the identified biomarkers.

The Optimized Priming Effect of FGF-1 and FGF-2 Enhances Preadipocyte Lineage Commitment in Human Adipose-Derived Mesenchymal Stem Cells

[Genes To Cells] To improve safety and graft vitality and to reduce unwanted lineage differentiation, this study refined the methodology by priming adipose-derived MSCs into preadipocytes—unipotent, self-renewing cells.

Brg1/PRMT5 Nuclear Complex Epigenetically Regulates FOXO1 in IPF Mesenchymal Progenitor Cells

[American Journal Of Physiology-Lung Cellular And Molecular Physiology] Investigators hypothesized that a Brg1/PRMT5 nuclear complex epigenetically regulates critical nodes in idiopathic pulmonary fibrosis mesenchymal progenitor cell (IPF MPC) self-renewal signaling networks. IPF and control MPCs were isolated from primary mesenchymal cell lines established from IPF and control patients.

XYA-2: A Marine-Derived Compound Targeting Apoptosis and Multiple Signaling Pathways in Pancreatic Cancer

[PeerJ] Investigators investigated the impact of XYA-2, a nitrogenated azaphilon previously reported from a deep-sea-derived fungus on the progression of pancreatic cancer cells.

Altered Histone Acetylation Patterns in Pancreatic Cancer Cell Lines Induce Subtype-Specific Transcriptomic and Phenotypical Changes

[Journal Of Oncology] Researchers determined if drug‑induced epigenetic reprogramming of pancreatic cancer cells affects PDAC subtype identity and chemosensitivity. Classical and basal‑like PDAC cell lines PaTu‑S, Capan‑1, Capan‑2, Colo357, PaTu‑T, PANC‑1, and MIAPaCa‑2, were treated for a short and long period with histone acetyltransferase and histone deacetylase inhibitors.

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