Researchers performed a genome-wide CRISPR/Cas9 screen in MCF7 breast cancer cells to identify genes whose loss of function reversed Beclin 1-dependent inhibition of cellular proliferation.
[Proceedings of the National Academy of Sciences of the United States of America]
Wijshake, T., Zou, Z., Chen, B., Zhong, L., Xiao, G., Xie, Y., Doench, J. G., Bennett, L., & Levine, B. (2021). Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin. Proceedings of the National Academy of Sciences, 118(5). https://doi.org/10.1073/pnas.2020478118 Cite
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