Publication

[International Immunopharmacology] Researchers identified aortic macrophage as the main expressing cell of gasdermin D (GSDMD) in aortic aneurysm.

[Biochemical and Biophysical Research Communications] To explore the mechanism underlying the action of anti-OX40 agonists to improve the anti-tumor efficacy, scientists analyzed the dynamic changes of tumor-infiltrating immune cells at different days post-treatments using single-cell RNA-sequencing.

[Advanced Healthcare Materials] A novel method for fully automated size classification and handling of cell aggregates like spheroids and organoids was presented. Using microfluidic flow generated by a piezoelectric droplet generator, aggregates were aspirated from a reservoir on one side of a thin capillary and deposited on the other side, encapsulated in free-flying nanoliter droplets to a target.

[Translational Psychiatry] To model the neuropathology of schizophrenia during early critical periods of brain development, the authors utilized patient-derived iPSCs to generate 3D cerebral organoids and define cell-specific signatures of disease.

[Advanced Healthcare Materials] Scientists developed a modular, tubeless fluidic circuit board coupled with reversibly sealed cell culture bricks for dynamic culture of ESC-derived thyroid follicles.

[Cancer Letters] Researchers reported the ex vivo modeling of acquired drug resistance by creating a pancreatic ductal adenocarcinoma patient-derived tumor organoid model harboring a rare BRAF R506_K507ins VLR mutation resulting in a resistance to trametinib, a MEK inhibitor.