Resveratrol Inhibits the Tumor Migration and Invasion by Upregulating TET1 and Reducing TIMP2/3 Methylation in Prostate Carcinoma Cells

Resveratrol inhibited the migration and invasion of prostate cancer cells, promoted the demethylation of tissue inhibitor of metalloproteinases (TIMP)2 and TIMP3 to upregulate their expressions, and suppressed the expressions of MMP2 and MMP9.
[Prostate]
Resveratrol inhibits the tumor migration and invasion by upregulating TET1 and reducing TIMP2/3 methylation in prostate carcinoma cells - Wang - - The Prostate - Wiley Online Library. (n.d.). Retrieved June 19, 2020, from https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.24029 Cite
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Altered Staining Patterns and Expression Level of Engrailed-2 in Benign Prostatic Hyperplasia and Prostate Cancer Predict Prostatic Disease Progression

Scientists showed that their homemade engrailed-2 (EN2) monoclonal antibody could specifically bind endogenous and exogenous EN2 protein in three different prostate cancer cell lines.
[BMC Cancer]
Li, Q., Shi, Y., Sa, R., Hao, J., Hu, J., Xiao, M., Wang, C., Yan, L., Qiao, B., & Chen, G. (2020). Altered staining patterns and expression level of Engrailed-2 in benign prostatic hyperplasia and prostate Cancer predict prostatic disease progression. BMC Cancer, 20(1), 555. https://doi.org/10.1186/s12885-020-07049-z Cite
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The miR-1908/SRM Regulatory Axis Contributes to Extracellular Vesicle Secretion in Prostate Cancer

Researchers investigated the target genes of miR-1908 by siRNA screening and identified that spermidine synthase was the key regulator of extracellular vesicle secretion in 22Rv1 cells.
[Cancer Science]
Urabe, F., Kosaka, N., Sawa, Y., Ito, K., Kimura, T., Egawa, S., Ochiya, T., & Yamamoto, Y. (n.d.). The miR-1908/SRM regulatory axis contributes to extracellular vesicle secretion in prostate cancer. Cancer Science, n/a(n/a). https://doi.org/10.1111/cas.14535 Cite
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Urupocidin C: A New Marine Guanidine Alkaloid which Selectively Kills Prostate Cancer Cells via Mitochondria Targeting

Researchers discovered a promising selectivity of both alkaloids for human prostate cancer cells, including highly drug-resistant lines, compared to non-malignant cells.
[Scientific Reports]
Dyshlovoy, S. A., Kudryashova, E. K., Kaune, M., Makarieva, T. N., Shubina, L. K., Busenbender, T., Denisenko, V. A., Popov, R. S., Hauschild, J., Fedorov, S. N., Bokemeyer, C., Graefen, M., Stonik, V. A., & von Amsberg, G. (2020). Urupocidin C: a new marine guanidine alkaloid which selectively kills prostate cancer cells via mitochondria targeting. Scientific Reports, 10(1), 9764. https://doi.org/10.1038/s41598-020-66428-5 Cite
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AR and ERG Drive the Expression of Prostate Cancer Specific Long Noncoding RNAs

In vitro validations confirmed that androgen receptor and ETS-related gene (ERG) regulated a subset of TPCATs, most notably for EPCART.
[Oncogene]
Kohvakka, A., Sattari, M., Shcherban, A., Annala, M., Urbanucci, A., Kesseli, J., Tammela, T. L. J., Kivinummi, K., Latonen, L., Nykter, M., & Visakorpi, T. (2020). AR and ERG drive the expression of prostate cancer specific long noncoding RNAs. Oncogene, 1–11. https://doi.org/10.1038/s41388-020-1365-6 Cite
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KLF5 Inhibits STAT3 Activity and Tumor Metastasis in Prostate Cancer by Suppressing IGF1 Transcription Cooperatively with HDAC1

Scientists knocked down KLF5 in prostate cancer cells and found that KLF5 knockdown promoted invasive ability of prostate cancer cells in vitro and in vivo .
[Cell Death & Disease]
Ma, J.-B., Bai, J.-Y., Zhang, H.-B., Jia, J., Shi, Q., Yang, C., Wang, X., He, D., & Guo, P. (2020). KLF5 inhibits STAT3 activity and tumor metastasis in prostate cancer by suppressing IGF1 transcription cooperatively with HDAC1. Cell Death & Disease, 11(6), 1–14. https://doi.org/10.1038/s41419-020-2671-1 Cite
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Isoprenylcysteine Carboxylmethyltransferase Is Required for the Impact of Mutant KRAS on TAZ Protein Level and Cancer Cell Self-Renewal

The authors found that suppression of isoprenylcysteine carboxylmethyltransferase resulted in reduced self-renewal/stemness in KRAS-driven pancreatic and breast cancer cells.
[Oncogene]
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Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia

Scientists report that a positive modulator of canonical WNT signaling pathway, RSPO-LGR4, upregulates key self-renewal genes and is essential for leukemia stem cell self-renewal in a subset of acute myeloid leukemia.
[Cell Stem Cell]
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S100A6 Is a Critical Regulator of Hematopoietic Stem Cells

Researchers showed that S100A6 regulated intracellular and mitochondria calcium buffering of HSC upon cytokine stimulation and have demonstrated that Akt activator SC79 reverted the levels of intracellular and mitochondrial calcium in HSC.
[Leukemia]
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A Missense Mutation in the MLKL Brace Region Promotes Lethal Neonatal Inflammation and Hematopoietic Dysfunction

The authors isolated a mouse strain with a single missense mutation, MlklD139V, that altered the two-helix ‘brace’ that connects the killer four-helix bundle and regulatory pseudokinase domains.
[Nature Communications]
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YBX1 Mediates Autophagy by Targeting p110β and Decreasing the Sensitivity to Cisplatin in NSCLC

Scientists analyzed the expression and clinical significance of Y-box binding protein 1 and markers of autophagy in NSCLC and examined their roles in regulating sensitivity to cisplatin in NSCLC.
[Cell Death & Disease]
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