Publication

[Signal Transduction And Targeted Therapy] The authors reported that neddylation inactivation with MLN4924, a specific inhibitor of NEDD8-activating enzyme E1, or genetic abrogation of Ube2m in T cells decreased double-negative T cell accumulation and attenuated murine lupus development.

[Nature Metabolism] The authors showed that heterochromatin markers, including histone H3K9 di/tri-methylation and HP1, decreased with age in muscle stem cells as a consequence of the depletion of the methyl donor S-adenosylmethionine.

[Molecular Systems Biology] Investigators combined live-cell imaging and machine learning to monitor ERK1/2-inhibited primary murine skeletal muscle precursor cells, that transitioned rapidly and robustly from proliferating myoblasts to post-mitotic myocytes and then fuse, forming multinucleated myotubes.

[Scientific Reports] The morphological changes and association between serping1 and α-syn were investigated in the colon of the 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-induced chronic Parkinson’s disease model.

[Nature Communications] Researchers used combined transcriptomic data derived from peripheral blood mononuclear cells of heart failure patients, both with and without CHIP, and cardiac tissue.

[EMBO Journal] The authors investigated the functional involvement of MITOL in HSC maintenance by generating MX1-cre inducible Mitol knockout mice.