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SPRTN Is Involved in Hepatocellular Carcinoma Development Through the ER Stress Response

[Cancer Gene Therapy] Researchers analyzed SPRTN and UPR in 21 human HCC tissue samples using RT-qPCR, immunoblot, and immunohistochemistry. They found alterations in the expression levels of SPRTN and UPR-related genes and proteins in HCC samples.

Construction of a ceRNA Regulatory Network to Explore Potential Pathogenesis Mechanisms Involved in Human Hepatocellular Carcinoma

[Scientific Reports] Transcriptional profile analysis was used to analyse expression of circRNAs in HCC in this study. The top ten upregulated circRNAs were selected and validated by quantitative reverse transcription polymerase chain reaction in another 34 HCC patients.

Combination of Melt-Electrospun Poly-ε-Caprolactone Scaffolds and Hepatocyte-Like Cells from Footprint-Free hiPSCs to Create 3D Biohybrid Constructs for Liver Tissue Engineering

[Scientific Reports] 3D biohybrid constructs were created by combining hepatocyte-like cells derived from patient-specific footprint-free human induced pluripotent stem cells and 3D melt-electrospun poly-ε-caprolactone scaffolds.

Enhanced SREBP2-Driven Cholesterol Biosynthesis by PKCλ/ι Deficiency in Intestinal Epithelial Cells Promotes Aggressive Serrated Tumorigenesis

[Nature Communications] Researchers demonstrated that the phosphorylation of SCAP by the atypical PKC, PKCλ/ι promote its degradation and inhibits the processing and activation of SREBP2, the master regulator of cholesterol biosynthesis.

Unveiling the Role of miR-137-3p/miR-296-5p/SERPINA3 Signaling in Colorectal Cancer Progression: Integrative Analysis of Gene Expression Profiles and In Vitro Studies

[BMC Medical Genomics] The role of miR-137-3p/miR-296-5p/ Serpin family A member 3 (SERPINA3) in CRC cell function was investigated using in vitro assays.

Cepharanthine, a Regulator of keap1-Nrf2, Inhibits Gastric Cancer Growth Through Oxidative Stress and Energy Metabolism Pathway

[Cell Death Discovery] Cepharanthine (CEP) inhibited the cellular activity of gastric cancer AGS, HGC27 and MFC cell lines in this study. CEP-induced apoptosis reduced Bcl-2 expression and increased cleaved caspase 3, cleaved caspase 9, Bax, and Bad expression.

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