Publication

[Molecular Metabolism] Using patient-derived iPSCs and mutated hESCs, researchers detected accumulation of misfolded proinsulin and impaired proinsulin processing in vitro, and a dominant-negative effect of these mutations on beta-cell mass and function after transplantation into mice.

[Developmental Cell] Investigators identified cellular rearrangements between acinar and ductal progenitors as a mechanism to drive branching morphogenesis in the pancreas while preserving the integrity of the acinar-ductal functional unit.

[Scientific Reports] Researchers investigated the effects of the two ANO1-inhibitors niclosamide and benzbromarone in vitro and in vivo in mouse models for cystic fibrosis and asthma.

[NPJ Precision Oncology] In addition to mapping the intratumoral heterogeneity of consensus molecular subtypes and their microenvironment, researchers identified cell communication events in the tumor-stroma interface of consensus molecular subtype 2 carcinomas.

[Phytotherapy Research] The role of SIRT1/GLUT1 signaling was investigated in the apoptotic effect of Leptosidin from Coreopsis grandiflora in DU145 and PC3 human prostate cancer cells.

[Journal Of Nanobiotechnology] By exploiting the recognition properties of lactoferrin receptors that target intestinal epithelial cells and prostate epithelial cells, a pathway was established for the transrectal absorption of Emodin to effectively reach the prostate.