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Silencing hsa_circ_0032449 Inhibits the Pancreatic Differentiation of Human Embryonic Stem Cells via the hsa_miR-195-5p/CCND1/PI3K/AKT Signaling Pathway

[Experimental Cell Research] Pancreatic specification is essential for stem cell-derived β cells cell induction in vitro and low-quality pancreatic progenitor (PP) cells may convert into derivatives of non-pancreatic lineages both in vivo and in vitro, impeding PP-derived β cell safety and differentiation efficiency.

Metabolic Regulatory Network Kinetic Modeling with Multiple Isotopic Tracers for iPSCs

[Biotechnology And Bioengineering] A metabolic kinetic model was developed to characterize the underlying mechanisms of iPSC culture process, which could predict cell response to environmental perturbation and support process control.

Applications of Plant-made Fibroblast Growth Factor for Human Pluripotent Stem Cells

[Stem Cells And Development] Scientists used rice cell-made basic fibroblast growth factor (RbFGF) to propagate hESCs and hiPSCs for at least 8 passages. Both hESCs and hiPSCs cultured with RbFGF not only maintained the morphology but also the specific expression of PSCs.

Evaluating the In Vitro Developmental Toxicity Potency of a Series of Petroleum Substance Extracts Using New Approach Methodologies (NAMs)

[Archives Of Toxicology] The authors evaluated the in vitro developmental toxicity and the possible underlying mode of action of DMSO extracts of a series of highly complex petroleum substances in the mouse ESC test, the zebrafish embryotoxicity test and the aryl hydrocarbon receptor reporter gene assay.

Loss of Cohesin Regulator PDS5A Reveals Repressive Role of Polycomb Loops

[Nature Communications] Using a CRISPR screen in mouse embryonic stem cells, investigators found that the cohesin regulator PDS5A links transcriptional silencing by Polycomb and 3D genome organization.

Tissue-Specific Populations From Amniotic Fluid-Derived Mesenchymal Stem Cells Manifest Variant In Vitro and In Vivo Properties

[Human Cell] Researchers found that the amniotic fluid derived MSCs (AFMSCs) could be categorized into three distinct groups: kidney-specific AFMSCs, lung-specific AFMSCs, and AFMSCs with an undefined tissue source.

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