Tag results:
Publication
ESC & iPSC News
Silencing hsa_circ_0032449 Inhibits the Pancreatic Differentiation of Human Embryonic Stem Cells via the hsa_miR-195-5p/CCND1/PI3K/AKT Signaling Pathway
[Experimental Cell Research] Pancreatic specification is essential for stem cell-derived β cells cell induction in vitro and low-quality pancreatic progenitor (PP) cells may convert into derivatives of non-pancreatic lineages both in vivo and in vitro, impeding PP-derived β cell safety and differentiation efficiency.
ESC & iPSC News
Metabolic Regulatory Network Kinetic Modeling with Multiple Isotopic Tracers for iPSCs
[Biotechnology And Bioengineering] A metabolic kinetic model was developed to characterize the underlying mechanisms of iPSC culture process, which could predict cell response to environmental perturbation and support process control.
ESC & iPSC News
Applications of Plant-made Fibroblast Growth Factor for Human Pluripotent Stem Cells
[Stem Cells And Development] Scientists used rice cell-made basic fibroblast growth factor (RbFGF) to propagate hESCs and hiPSCs for at least 8 passages. Both hESCs and hiPSCs cultured with RbFGF not only maintained the morphology but also the specific expression of PSCs.
ESC & iPSC News
Evaluating the In Vitro Developmental Toxicity Potency of a Series of Petroleum Substance Extracts Using New Approach Methodologies (NAMs)
[Archives Of Toxicology] The authors evaluated the in vitro developmental toxicity and the possible underlying mode of action of DMSO extracts of a series of highly complex petroleum substances in the mouse ESC test, the zebrafish embryotoxicity test and the aryl hydrocarbon receptor reporter gene assay.
ESC & iPSC News
Loss of Cohesin Regulator PDS5A Reveals Repressive Role of Polycomb Loops
[Nature Communications] Using a CRISPR screen in mouse embryonic stem cells, investigators found that the cohesin regulator PDS5A links transcriptional silencing by Polycomb and 3D genome organization.
Newsletters
Tissue-Specific Populations From Amniotic Fluid-Derived Mesenchymal Stem Cells Manifest Variant In Vitro and In Vivo Properties
[Human Cell] Researchers found that the amniotic fluid derived MSCs (AFMSCs) could be categorized into three distinct groups: kidney-specific AFMSCs, lung-specific AFMSCs, and AFMSCs with an undefined tissue source.