Publication

[Biomedicine & Pharmacotherapy] Human pulmonary fibroblasts were transfected with miR-29a-3p, and RT-qPCR, immunostaining, and western blotting were performed to determine the expression of DNMT3A and extracellular matrix collagen-1 and fibronectin-1 levels.

[ACS Applied Materials & Interfaces] Investigators successfully validated the pivotal role of activating transcription factor 5 (ATF5) in upregulating the UPRmt, mitigating IL-1β-induced inflammation and mitochondrial dysfunction, and promoting balanced metabolism in articular cartilage ECM, proving its potential as a promising therapeutic target for osteoarthritis.

[Nature Communications] To understand the mechanistic significance of inter-regional projections on development of neural circuits, researchers investigated an in vitro neural tissue model for inter-regional connections, in which two cerebral organoids are connected with a bundle of reciprocally extended axons.

[Biomedicine & Pharmacotherapy] Scientists aimed to characterize the effect of calprotectin on mouse jejunal organoids as a model epithelium, focusing on Zn2+ metabolism and cell proliferation.

[Journal Of Neurovirology] Researchers generated and characterized several human-induced pluripotent stem cell lines from healthy human donor skin fibroblast cells. hiPSCs were then used for the generation of microglia-containing human cerebral organoids.

[Cell Reports] Scientists indicated that increasing the cellular complexity of the organoid microenvironment promoted the emergence of oRG and supported a platform to study the outer radial glia in human pluripotent stem cells-derived brain organoids routinely.