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Gasdermin C Sensitizes Tumor Cells to PARP Inhibitor Therapy in Cancer Models

[European Journal Of Clinical Investigation] Scientists showed that gasdermin C sensitized tumor cells to several poly (ADP-ribose) polymerase inhibitors in vitro and in immunocompetent mice and caused durable tumor regression in an immune-dependent manner.

Theranostic Role of 89Zr- and 177Lu-Labeled Aflibercept in Breast Cancer

[European Journal Of Nuclear Medicine And Molecular Imaging] Aflibercept was radiolabeled with 89Zr and 177Lu via the conjugation of chelators. Flow cytometry and cell immunofluorescent staining were performed to evaluate the binding affinity of Abe.

Nomogram Model for Predicting Invasive Placenta in Patients with Placenta Previa: Integrating MRI Findings and Clinical Characteristics

[Scientific Reports] Investigators validated a nomogram model that predicts invasive placenta in patients with placenta previa, utilizing MRI findings and clinical characteristics. A retrospective analysis was conducted on a training cohort of 269 patients from the Second Affiliated Hospital of Fujian Medical University and a validation cohort of 41 patients from Quanzhou Children’s Hospital.

Debulking Corneal Biopsy with Tectonic Amniotic Membrane Transplantation in Refractory Clinically Presumed Fungal Keratitis

[Scientific Reports] The authors highlight both the diagnostic and therapeutic roles of corneal biopsy together with amniotic membrane transplantation in patients with refractory clinically presumed fungal keratitis.

Human Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Alleviate Hypoxia-Induced Pulmonary Arterial Hypertension in Mice via Macrophages Get Access Arrow

[Stem Cells] Scientists investigated whether the human umbilical cord mesenchymal stromal cell-derived exosomes could improve the lung inflammatory microenvironment and inhibit pulmonary vascular remodeling by targeting macrophages and identifying the underlying mechanisms.

The Therapeutic Role of SSEA3(+) Human Umbilical Cord Blood Mononuclear Cells in Ischemic Stroke Model

[Neuroscience Research] Researchers isolated stage-specific embryonic antigen 3 (SSEA3) positive cells from healthy umbilical cord blood (UCB) mononuclear cells, which comprised about 7.01% of the total UCB-mononuclear cells.

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