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Vascularized Liver-on-a-Chip Model to Investigate Nicotine-Induced Dysfunction

[Biomicrofluidics] A systematic approach to investigating the initial seeding density of endothelial cells and its effects on interconnected networks was taken and combined with hepatic spheroids to form a liver-on-a-chip model.

bFGF-Releasing Biodegradable Nanoparticles for Effectively Engrafting Transplanted Hepatocyte Sheet

[Journal Of Controlled Release] Scientists aimed to develop basic fibroblast growth factor (bFGF)-releasing nanoparticles to prolong the survival of hepatocyte sheets after transplantation.

Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz(Wwtr1) Activation in Male LDLR-/- Mice

[Endocrinology] Researchers showed that Wnt16 protein accumulated in murine and human vascular smooth muscle

Distinct Roles of Hematopoietic Cytokines in the Regulation of Leukemia Stem Cells in Murine MLL-AF9 Leukemia

[Stem Cell Reports] Using an MLL-AF9-induced murine acute myeloid leukemia model, researchers studied the role of hematopoietic cytokines in the survival of lymphoid-primed multipotent progenitor- and granulocyte-monocyte progenitor-like leukemia stem cells.

Loss of α-1,2-Mannosidase MAN1C1 Promotes Tumorigenesis of Intrahepatic Cholangiocarcinoma through Enhancing CD133-FIP200 Interaction

[Cell Reports] Investigators found that the level of α-1,2-mannosylated CD133 was associated with the level of stemness genes in intrahepatic cholangiocarcinoma tissues. α-1,2-mannosylated CD133+ cells possessed the characteristics of tumor-initiating cells.

An ERK5-PFKFB3 Axis Regulates Glycolysis and Represents a Therapeutic Vulnerability in Pediatric Diffuse Midline Glioma

[Cell Reports] Scientists established that ERK5 was a critical regulator of cell proliferation and glycolysis in diffuse midline glioma with altered H3K27.

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