Publication

[Stem Cell Reports] The authors generated isogenic iPSCs carrying the hotspot OPA1 c.2708_2711delTTAG mutation and found that the mutant variant caused defective initial and terminal differentiation and abnormal electrophysiological properties of organoid-derived retinal ganglion cells.

[Science Translational Medicine] Researchers reported that wild-type isocitrate dehydrogenase 1 (IDH1) activated serine biosynthesis by enhancing the expression of phosphoglycerate dehydrogenase and phosphoserine aminotransferase 1.

[Biomaterials Research] Scientists synthesized a polymeric nanocarrier, hyaluronic acid-block-poly (HA-b-PCDA), and explored the use of HA-b-PCDA to simultaneously deliver chemotherapeutic drugs and eradicate breast cancer stem cells.

[Journal of Translational Medicine] Pancreatic tumor samples were collected from patients at Sun Yat-sen University Cancer Center, followed by immunofluorescence analysis.

[iScience] Genetic approaches revealed that endothelial cell-specific presenilin (Psen)-1 deletion did not improve elastin aortopathy whereas deletion of either Psen1 in smooth muscle cells (SMCs) or Psen2 globally attenuated Notch pathway and SMC proliferation, mitigating aortic disease.

[Cell Reports] Scientists used single-chain fast light- and activity-regulated expression 2 (scFLARE2), a temporally precise tagging system, to manipulate mouse lateral amygdala neurons active during one of two 3 min threat experiences occurring close or far in time.