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Intestinal Cell News
Partial In Vivo Reprogramming Enables Injury-Free Intestinal Regeneration via Autonomous Ptgs1 Induction
[Science Advances] Researchers induced dedifferentiation of intestinal epithelial cells using Oct4, Sox2, Klf4, and c-Myc (OSKM) in vivo. The OSKM-induced forced dedifferentiation showed similar molecular features of intestinal regeneration.
Intestinal Cell News
Enhancement of Efferocytosis through Biased FPR2 Signaling Attenuates Intestinal Inflammation
[EMBO Molecular Medicine] Scientists reported the identification of columbamine which enhanced macrophage-mediated efferocytosis and attenuated intestinal inflammation in a murine colitis model.
Intestinal Cell News
Remodeling of Intestinal Epithelium Derived Extracellular Vesicles by Nanoparticles and Its Bioeffect on Tumor Cell Migration
[Journal of Controlled Release] Researchers studied the interaction between nanoparticles and intestinal epithelial cells, as well as their bioeffects on downstream cells from the perspective of extracellular vesicles.
Intestinal Cell News
Mutant p53 Gain-of-Function Stimulates Canonical Wnt Signaling via PI3K/AKT Pathway in Colon Cancer
[Journal of Cell Communication and Signaling] Using the TCGA public data from Pan-Cancer and the GEPIA2 platform, an in silico analysis of wt-p53 versus mut-p53 genotyped colorectal cancer patients showed that TP53 and CTNNB1 were significantly overexpressed in colorectal cancer, compared with normal tissue.
Intestinal Cell News
Protease-Activated Receptor 2 Attenuates Doxorubicin-Induced Apoptosis in Colon Cancer Cells
[Journal of Cell Communication and Signaling] Scientists investigated a possible mechanistic link between PAR2 activation of intracellular signaling and pro-survival events in HT29 human colon cancer cells, then identified possible strategies to restore doxorubicin effects.
Intestinal Cell News
Arabinose Confers Protection against Intestinal Injury by Improving Integrity of Intestinal Mucosal Barrier
[International Immunopharmacology] Arabinose was recognized as a significant and inherent protector of the intestinal mucosal barrier through its role in preserving the integrity of tight junctions within the intestines.