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Partial In Vivo Reprogramming Enables Injury-Free Intestinal Regeneration via Autonomous Ptgs1 Induction

[Science Advances] Researchers induced dedifferentiation of intestinal epithelial cells using Oct4, Sox2, Klf4, and c-Myc (OSKM) in vivo. The OSKM-induced forced dedifferentiation showed similar molecular features of intestinal regeneration.

Enhancement of Efferocytosis through Biased FPR2 Signaling Attenuates Intestinal Inflammation

[EMBO Molecular Medicine] Scientists reported the identification of columbamine which enhanced macrophage-mediated efferocytosis and attenuated intestinal inflammation in a murine colitis model.

Remodeling of Intestinal Epithelium Derived Extracellular Vesicles by Nanoparticles and Its Bioeffect on Tumor Cell Migration

[Journal of Controlled Release] Researchers studied the interaction between nanoparticles and intestinal epithelial cells, as well as their bioeffects on downstream cells from the perspective of extracellular vesicles.

Mutant p53 Gain-of-Function Stimulates Canonical Wnt Signaling via PI3K/AKT Pathway in Colon Cancer

[Journal of Cell Communication and Signaling] Using the TCGA public data from Pan-Cancer and the GEPIA2 platform, an in silico analysis of wt-p53 versus mut-p53 genotyped colorectal cancer patients showed that TP53 and CTNNB1 were significantly overexpressed in colorectal cancer, compared with normal tissue.

Protease-Activated Receptor 2 Attenuates Doxorubicin-Induced Apoptosis in Colon Cancer Cells

[Journal of Cell Communication and Signaling] Scientists investigated a possible mechanistic link between PAR2 activation of intracellular signaling and pro-survival events in HT29 human colon cancer cells, then identified possible strategies to restore doxorubicin effects.

Arabinose Confers Protection against Intestinal Injury by Improving Integrity of Intestinal Mucosal Barrier

[International Immunopharmacology] Arabinose was recognized as a significant and inherent protector of the intestinal mucosal barrier through its role in preserving the integrity of tight junctions within the intestines.

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