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A Spinal Cord Neuroprosthesis for Locomotor Deficits Due to Parkinson’s Disease

[Nature Medicine] Investigators developed a neuroprosthesis operating in closed loop that targeted the dorsal root entry zones innervating lumbosacral segments to reproduce the natural spatiotemporal activation of the lumbosacral spinal cord during walking.

Glioma Synapses Recruit Mechanisms of Adaptive Plasticity

[Nature] Scientists indicated that brain-derived neurotrophic factor–tropomyosin-related kinase B signaling promoted malignant synaptic plasticity and augmented tumor progression.

Glycolysis-Derived Alanine from Glia Fuels Neuronal Mitochondria for Memory in Drosophila

[Nature Metabolism] Investigators uncovered in Drosophila melanogaster a glia-to-neuron alanine transfer involving alanine aminotransferase that sustained memory formation.

The Roles of Surround Inhibition for the Intrinsic Function of the Striatum, Analyzed In Silico

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists investigated the role of surround inhibition for the intrinsic function of the striatum.

PD-1 Signaling Negatively Regulates the Common Cytokine Receptor γ Chain via MARCH5-Mediated Ubiquitination and Degradation to Suppress Anti-Tumor Immunity

[Cell Research] Scientists showed that PD-1 ligation resulted in BATF-dependent transcriptional induction of the membrane-associated E3 ubiquitin ligase MARCH5.

Selective IL-27 Production by Intestinal Regulatory T Cells Permits Gut-Specific Regulation of TH17 Cell Immunity

[Nature Immunology] Researchers showed that IL-27 was specifically produced by intestinal Treg cells to regulate helper T17 cell (TH17 cell) immunity.

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