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Extracellular Matrix News
Single-Component Multilayered Self-Assembling Protein Nanoparticles Displaying Extracellular Domains of Matrix Protein 2 as a Pan-Influenza a Vaccine
[ACS Nano] Scientists designed and evaluated single-component self-assembling protein nanoparticles (SApNPs) presenting the conserved extracellular domain of matrix protein 2 as vaccine candidates against influenza A viruses.
Immunology of Infectious Disease News
Thrombocytopenia and Venous Thromboembolic Events After BNT162b2, CoronaVac, ChAdOx1 Vaccines and SARS-CoV-2 Infection: A Self-Controlled Case Series Study
[Scientific Reports] Scientists assessed the association between COVID-19 vaccines, SARS-CoV-2 infection and the risk of thrombocytopenia and venous thromboembolism.
Immunology of Infectious Disease News
Isolation May Select for Earlier and Higher Peak Viral Load but Shorter Duration in SARS-CoV-2 Evolution
[Nature Communications] Investigators found that the SARS-CoV-2 variants selected for as the virus evolved from the pre-Alpha to the Delta variant had earlier and higher peak in viral load dynamics but a shorter duration of infection.
Immunology of Infectious Disease News
Heat Inactivation of SARS-CoV 2 Enabled the Measurement of Salivary Cortisol During COVID-19 Pandemic
[Endocrine] Researchers speculated that the adoption of an appropriate technique to inactivate viral particles in saliva specimens allowed the safety maintenance of salivary collections, also during the SARS-CoV-2 outbreak.
Immunology of Infectious Disease News
HIV-1 Env Trimers Asymmetrically Engage CD4 Receptors in Membranes
[Nature] Investigators used cryo-electron tomography to monitor viral envelope glycoproteinCD4 interactions at the membrane–membrane interfaces formed between HIV-1 and CD4-presenting virus-like particles.
Immunology of Infectious Disease News
Intermediate Conformations of CD4-Bound HIV-1 Env Heterotrimers
[Nature] Researchers illuminated intermediate conformations of HIV-1envelope and illustrated its structural plasticity.