Publication

[Advanced Science] Investigators found that IGF2BP2 was highly expressed in TNBC due to the lower methylation level in its promoter region.

[Cell Reports] Scientists showed that a cohort of TNBC not only expressed androgen receptor (AR) at a much higher rate (∼80%) but also expressesd AR splice variants (∼20%), further subclassifying luminal AR-TNBC.

[Molecular Carcinogenesis] Researchers found that low expression of lncRNA SEMA3B-AS1 correlated with unfavorable survival in breast cancer patients. SEMA3B-AS1 was also downregulated in TNBC and linked to advanced tumor stage.

[ACS Nano] Researchers clarified the relationship between radiotherapy and cancer stemness and provided insights to achieve complete suppression of radioresistant hepatocellular carcinoma tumor by inhibiting cancer stemness.

[Cancer Gene Therapy] Scientists demonstrated that the upregulation of TNFRSF19 functioned as a tumor suppressor in TNBC by stimulating paraptosis through the activation of the MAPK pathway-mediated endoplasmic reticulum stress.

[Science Signaling] Investigators showed that these chemokines differentially interacted with ECM glycosaminoglycans (GAGs), which was enhanced by sulfation of specific GAGs.