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Discovery of Dolutegravir-1,2, 3-Triazole Derivatives against Prostate Cancer via Inducing DNA Damage

[Bioorganic Chemistry] A common drug against the human immunodeficiency virus (HIV), the dolutegravir was modified to become a series of dolutegravir-1,2,3-triazole derivatives.

S-adenosylmethionine Treatment Affects Histone Methylation in Prostate Cancer Cells

[Gene] The authors treated PC-3 cells with 200µmol SAM, a concentration known to cause anticancerogenic effects, followed by ChIP-sequencing for H3K4me3 and H3K27me3.

STEAP4 Modulates Cell Proliferation and Oxidative Stress in Benign Prostatic Hyperplasia

[Cellular Signalling] Scientists explored the expression, biological function, and underlying mechanism of STEAP4 in benign prostatic hyperplasia progress. Human prostate tissues and cell lines were utilized.

Fascin-1 Expression Is Associated with Neuroendocrine Prostate Cancer and Directly Suppressed by Androgen Receptor

[British Journal Of Cancer] Androgen or antagonist’s cellular treatments and knockdown experiments were used to detect changes in cell morphology, molecular markers, migration properties and in vivo tumor growth.

PTEN-Regulated PI3K-p110 and AKT Isoform Plasticity Controls Metastatic Prostate Cancer Progression

[Oncogene] Using prostate cancer (PC) cells isogenic for PTEN, researchers showed that PTEN-deficiency correlated with dependence on both p110β and AKT2 for in vitro and in vivo parameters of metastatic growth or motility, and with downregulation of SMAD4, a known PC metastasis suppressor.

Nucleophosmin 1 Cooperates with BRD4 to Facilitate C-Myc Transcription to Promote Prostate Cancer Progression

[Cell Death Discovery] Researchers showed that NPM1 is overexpressed in PCa cell lines and tissues and that the dysregulation of NPM1 promotes prostate cancer proliferation.

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