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RNA-Binding Protein NOVA1 Promotes Acute T-lymphocyte Leukemia Progression by Stabilizing USP44 mRNA

[Biochemistry And Cell Biology] The gain- and loss-of-function studies for neotumor ventral antigen-1 (NOVA1) were performed using lentivirus-mediated NOVA1 overexpression/knockdown in Jurkat and CCRF-CEM cells.

Hematopoietic Stem Cells Suppress Proliferation and Enhance Differentiation of Leukemia Cells Through Regulating Apoptotic and Inflammatory Genes

[Journal Of Cancer Research And Clinical Oncology] Investigators demonstrated the growth-restraining function of HSCs in acute leukemia treatment. The viability, proliferation, apoptosis, and differentiation of leukemia cells were evaluated by cell counting, CCK-8, and flow cytometry analysis.

SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells

[Inflammation] Investigators hypothesized that sirtuin 6 (SIRT6) suppressed inflammatory response in human lung microvascular cells and ensued monocyte adhesion to endothelial cells.

On-Site Construction of a Full-Thickness Skin Equivalent with Endothelial Tube Networks via Multilayer Electrospinning for Wound Coverage

[ACS Biomaterials Science & Engineering] Coculture of vascular endothelial cells, circulating fibrocytes, and fibroblasts within the 5L dermis displayed network formation in vitro, resulting in reduced inflammatory factor levels and enhanced integration with the host vasculature in vivo.

Gestational Intermittent Hypoxia Induces Endothelial Dysfunction and Hypertension in Pregnant Rats: Role of Endothelin Type B Receptor

[Biology Of Reproduction] Researchers tested the hypothesis that intermittent hypoxia, a hallmark of obstructive sleep apnea, induced gestational hypertension through perturbed endothelin-1 signaling.

Eosinophils Promote Pulmonary Matrix Destruction and Emphysema via Cathepsin L

[Signal Transduction And Targeted Therapy] Investigators employed single-cell RNA sequencing to identify eosinophil subgroups in mouse models of asthma and emphysema, followed by functional analyses of these subgroups.

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