Publication

[npj Precision Oncology] Researchers retrospectively analyzed 1011 lung cancer patients whose tumor samples were successfully profiled by high-throughput sequencing panel including genomic instability/homologous recombination deficiency score.

[Oncogenesis] Investigators found that Beta1,4-galactosyltransferase (B4GALT) 1 was significantly downregulated in HCC tissue compared with the adjacent liver tissue, and low B4GALT1 expression was associated with vascular invasion and poor overall survival in patients with HCC.

[Scientific Reports] The authors investigated the regulatory and transcriptional landscape in fatty livers and liver tumors from DIAMOND mice that faithfully mimicked human HCC development in the context of metabolic associated fatty liver disease.

[Stem Cells International] Researchers reported a new function of TG2 in the regulation of MSC redox homeostasis. During in vitro MSC expansion, TG2 was required for cell proliferation and self-renewal by preventing premature senescence but had no effect on the expression of surface antigens and oxidative stress-induced cell death.

[Phytotherapy Research] An ovariectomy-induced osteoporosis mouse model and bone marrow mesenchymal stem cells were used to analyze the effects of isoliquiritin on bone regeneration in vivo and in vitro, respectively.

[Arthritis Research & Therapy] A chimeric human/mouse model of synovitis was created by surgically implanting SCID mice with a piece of human articular cartilage surrounded by RASF. Mice were injected once with either GMSC or GMSCExo at 5–7 days post-implantation.