Regulation of Autophagy by Protein Kinase C-ε in Breast Cancer Cells

Reasearchers showed that protein kinase C-ε promoted breast cancer cell survival not only by inhibiting apoptosis but also by inducing autophagy.
[International Journal of Molecular Sciences]
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Oncogene PRR14 Promotes Breast Cancer through Activation of pI3K Signal Pathway and Inhibition of CHEK2 Pathway

Investigators showed PRR14 contributed to breast carcinogenesis mainly through overexpression, which derived from elevated transcription and gene amplification.
[Cell Death & Disease]
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Antitumor Effect of a WEE1 Inhibitor and Potentiation of Olaparib Sensitivity by DNA Damage Response Modulation in Triple-Negative Breast Cancer

Scientists investigated the antitumor effects of a WEE1 inhibitor and the mechanisms responsible for its effects on the cell cycle and DNA repair pathway as a monotherapy and in combination with a PARP inhibitor, an ATR inhibitor, and a DNA damage-inducing agent in six TNBC cell lines and in a Balb/c athymic nude mouse xenograft model.
[Scientific Reports]
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Intercellular Adhesion Stiffness Moderates Cell Decoupling as a Function of Substrate Stiffness

Researchers modeled a three-dimensional cell pair on a patterned substrate, a simple laboratory setup to study intercellular interactions. They explicitly modeled focal adhesions and adherens junctions. These mechanosensing adhesions matured, becoming stabilized by force.
[Biophysical Journal]
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Nanoparticle Delivery of Immunostimulatory Oligonucleotides Enhances Response to Checkpoint Inhibitor Therapeutics

Researchers found that their engineered nanoparticles carrying a CpG DNA ligand of TLR9 could suppress tumor growth in several animal models of various cancers, resulting in an abscopal effect on distant tumors, and improving responsiveness to anti-CTLA4 treatment with combinatorial effects after intratumoral administration.
[Proceedings of the National Academy of Sciences of the United States of America]
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Allosteric Communications between Domains Modulate the Activity of Matrix Metalloprotease-1

Investigators showed that communications between the catalytic and hemopexin domains of matrix metalloprotease-1 on type-1 collagen fibrils correlated with its activity.
[Biophysical Journal]
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LiQD Cornea: Pro-Regeneration Collagen Mimetics as Patches and Alternatives to Corneal Transplantation

The self-assembling, fully defined, synthetic collagen analog is much less costly than human recombinant collagen and reduced the risk of immune rejection associated with xenogeneic materials.
[Science Advances]
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3D Printed Deformable Sensors

The authors developed an in situ 3D printing system that estimated the motion and deformation of the target surface to adapt the toolpath in real time. With this printing system, a hydrogel-based sensor was printed on a porcine lung under respiration-induced deformation.
[Science Advances]
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Humidity‐Triggered Relaxation of Polyelectrolyte Complexes as a Robust Approach to Generate Extracellular Matrix Biomimetic Films

Scientists report a facile approach to generate ECM biomimetic films based on the humidity‐triggered relaxation of polyelectrolyte complex nanoparticles.
[Advanced Healthcare Materials]
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Systemically Comparing Host Immunity between Survived and Deceased COVID-19 Patients

Scientists summarized the characteristics of cellular immune responses in a total of 157 COVID-19 patients enrolled in Tongji Hospital between February and March 2020 and compare the properties between 95 survived and 62 deceased patients with different onset time.
[Cellular & Molecular Immunology]
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Optimization of Primer Sets and Detection Protocols for SARS-CoV-2 of Coronavirus Disease 2019 (COVID-19) Using PCR and Real-Time PCR

Scientists provide three-step guidelines for the design and optimization of specific primer sets. The three steps include the selection of primer sets for target genes in the genome of SARS-CoV-2, the in silico validation of primer and amplicon sequences, and the optimization of PCR conditions for specific hybridization between the primers and target genes, and the elimination of spurious primer dimers.
[Experimental and Molecular Medicine]
Optimization of primer sets and detection protocols for SARS-CoV-2 of coronavirus disease 2019 (COVID-19) using PCR and real-time PCR | Experimental & Molecular Medicine. (n.d.). Retrieved June 17, 2020, from https://www.nature.com/articles/s12276-020-0452-7 Cite
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