Publication

[Experimental & Molecular Medicine] Researchers' analysis in a mouse model revealed that β cells of multiparous mice lost their proliferative capacity and became unable to compensate for the increasing insulin demand, leading to hyperglycemia.

[International Immunopharmacology] Researchers investigated the role of high-density lipoprotein (HDL) in pancreatic necrosis in acute pancreatitis (AP). The roles of healthy human-derived HDL and apoA-I mimic peptide D4F were demonstrated in AP models in vivo and in vitro.

[3 Biotech] MMP assay and western blot was conducted to investigate the effects of atorvastatin on apoptotic cascade with sesamol as a protective agent was conducted in MIN-6 cells.

[Nature Communications] Investigators showed that Lin28b/let-7 pathway was indispensable for modulating the expression of Wnt5a in tumor epithelium, which could be secreted and then up-regulated Lin28b in cancer-associated fibroblasts.

[eLife] The authors synthesized a novel pro-drug of triptolide which was formulated into an emulsion for in vitro and in vivo testing in rats and mice, and using human pancreatic cancer cell lines and patient-derived pancreatic tumor organoids.

[Scientific Reports] Scientists investigated the effect of angiopoietin-2 (Ang-2) protein in PDAC survival. They did so by comparing the associaton between circulating Ang-2 using enzyme-linked immunosorbent assay and the pancreatic tumor expression of Ang-2 using immunohistochemistry.