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Anti-Inflammatory and Anti-Oxidant Impacts of Lentinan Combined with Probiotics in Ulcerative Colitis

[Molecular Biotechnology] An HT-29 cell model of colitis was established by dextran sulfate sodium stimulation and cultured with lentinan and/or probiotics to examine cell proliferation and apoptosis.

Lipid Metabolism of Plasma-Derived Small Extracellular Vesicles in COVID-19 Convalescent Patients

[Scientific Reports] Researchers examined the small extracellular vesicle lipid profile of plasma of recovered COVID-19 patients (RCs). Their study may offer new insights into the mechanism of organ dysfunction and help identify novel therapeutic targets in the RCs.

Mpox Virus Infection and Drug Treatment Modelled in Human Skin Organoids

[Nature Microbiology] Scientists demonstrated that human-induced pluripotent stem cell-derived skin organoids are susceptible to Mpox virus infection and support infectious virus production.

RNA-Binding Protein NOVA1 Promotes Acute T-lymphocyte Leukemia Progression by Stabilizing USP44 mRNA

[Biochemistry And Cell Biology] The gain- and loss-of-function studies for neotumor ventral antigen-1 (NOVA1) were performed using lentivirus-mediated NOVA1 overexpression/knockdown in Jurkat and CCRF-CEM cells.

Hematopoietic Stem Cells Suppress Proliferation and Enhance Differentiation of Leukemia Cells Through Regulating Apoptotic and Inflammatory Genes

[Journal Of Cancer Research And Clinical Oncology] Investigators demonstrated the growth-restraining function of HSCs in acute leukemia treatment. The viability, proliferation, apoptosis, and differentiation of leukemia cells were evaluated by cell counting, CCK-8, and flow cytometry analysis.

SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells

[Inflammation] Investigators hypothesized that sirtuin 6 (SIRT6) suppressed inflammatory response in human lung microvascular cells and ensued monocyte adhesion to endothelial cells.

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