Publication

[Macromolecular Bioscience] To modulate matrix stiffness, methacrylate groups were introduced into both decellularized porcine pulmonary ECM and hyaluronic acid, followed by photocrosslinking with photoinitiator.

[Stem Cell Research & Therapy] Human embryonic stem cells-derived hepatocyte-like cells were generated through multistage differentiation in 2D and 3D cultures, incorporating either type I collagen or Matrigel during hepatic specification and maturation.

[Molecular Psychiatry] Consistent with the accumulation of ECM in the hippocampus researchers observed with aging, scientists found that TIMP2 acted to reduce accumulation of ECM around synapses in the hippocampus.

[Nature Communications] The authors revealed that cells decode the steady-state concentrations and timing of YAP activation to control proliferation, cell fate, and expression of the pluripotency regulators Oct4 and Nanog.

[iScience] Scientists developed a step-wise protocol that differentiated iPSCs from individuals homozygous for the C-C chemokine receptor type 5 (CCR5)Δ32 variant and healthy volunteers into myeloid lineage induced monocytes and macrophages.

[Biofabrication] Researchers designed a perfusion bioreactor for an hiPSC-laden, 3D-bioprinted chamber with the goal of proliferating the hiPSCs throughout the structure prior to differentiation to generate a thick tissue model.