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Iron Overload Induces Dysplastic Erythropoiesis and Features of Myelodysplasia in Nrf2-Deficient Mice

[Leukemia] Scientists investigated erythropoiesis and the development of myelodysplasia in mouse models of iron overload and compromised antioxidant response.

Complete miRNA-15/16 Loss in Mice Promotes Hematopoietic Progenitor Expansion and a Myeloid-Biased Hyperproliferative State

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators demonstrated that the myeloproliferative phenotype in double knockout mice correlated with an increase of hematopoietic stem and progenitor cells early in life.

Akkermansia muciniphila Induces Slow Extramedullary Hematopoiesis via Cooperative IL-1R/TLR Signals

[EMBO Reports] Researchers found that systemic single injections of Akkermansia muciniphila, a mucin-degrading bacterium, rapidly activated bone marrow myelopoiesis and slowed long-lasting hepato-splenomegaly.

Identification of Multivariable microRNA and Clinical Biomarker Panels to Predict Imatinib Response in Chronic Myeloid Leukemia at Diagnosis

[Leukemia] Scientists analyzed clinical data and differentially expressed miRNAs in CD34+ chronic myeloid leukemia cells from 80 patients at diagnosis who were later classified as imatinib-responders or imatinib-nonresponders.

Low Doses of IFN-γ Maintain Self-Renewal of Leukemia Stem Cells in Acute Myeloid Leukemia

[Oncogene] Researchers found that low serum interferon-γ (IFN-γ) levels correlated with a higher percentage of leukemia stem cell and greater relapse incidence in AML patients.

Adjudin Improves Beta Cell Maturation, Hepatic Glucose Uptake, and Glucose Homeostasis

[Diabetologia] Researchers investigated the effects of adjudin, a small molecule identified in a beta cell screen using zebrafish, on pancreatic beta cells and diabetes conditions.

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