Publication

[Cancer Discovery] Researchers uncovered that KRAS* transforms the phenotype of carcinoma-associated fibroblasts (CAFs) into lipid–laden CAFs, promoting angiogenesis and tumor progression.

[Advanced Materials] The authors developed an oral pifithrin-α embedded nanomedicine to effectively treat inflammatory bowel disease by inhibiting excessive intestianl epithelial cell apoptosis.

[Cell Death & Disease] Researchers suggested that activated MRTF-A in the intestinal epithelium shifted the balance between proliferation, differentiation, and apoptosis.

[Free Radical Biology And Medicine] Investigators examined the synergistic therapeutic impact of combining erastin with a bioactive flavonoid compound luteolin on the ferroptosis-mediated suppression of colon cancer. Human colon cancer HCT116 and SW480 cells were used for the in vitro studies and a xenograft of colon cancer model in BALB/c nude mice was established for the in vivo experiments.

[Acta Pharmacologica Sinica] Scientists investigated whether the combination of rosmarinic acid and ginsenoside Rg1 could exert anti-metastatic effects against colorectal cancer. MC38 tumor xenograft mouse model with lung metastasis was established.

[Journal Of Biological Chemistry] Investigators examined the effects of SUMOylation on the expression pattern of hypoxia-inducible factor-1α in response to pan-hydroxylase inhibitor dimethyloxalylglycine in intestinal epithelial cells.