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Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity

[Cancer Discovery] Using a novel enzymatic inhibitor of the RNA methyl­transferase METTL3, the authors demonstrated that a global decrease in N6-methyladenosine resulted in double-stranded RNA formation and a profound cell-intrinsic interferon response.

Preexisting Tumor-Resident T Cells with Cytotoxic Potential Associate with Response to Neoadjuvant Anti–PD-1 in Head and Neck Cancer

[Science Immunology] Investigators identified reinvigoration of cytotoxicity among ZNF683+CD8+ T cells as a likely mechanism underlying response to neoadjuvant anti–PD-1 in head and neck cancer.

Exploiting a Rodent Cell Block for Intrinsic Resistance to HIV-1 Gene Expression in Human T Cells

[mBio] Researchers used precision CRISPR/Cas9 gene editing to engineer a “mousified” version of one such host protein, cyclin T1, in human T cells.

MAdCAM-1 Targeting Strategy Can Prevent Colitic Cancer Carcinogenesis and Progression via Suppression of Immune Cell Infiltration and Inflammatory Signals

[International Journal of Cancer] Scientists evaluated the expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1), CD31, and immune cell markers in samples surgically resected from 11 ulcerative colitis patients with dysplasia/colitic cancer and 17 patients with sporadic colorectal cancer.

Highly Multiplexed Spatial Analysis Identifies Tissue-Resident Memory T Cells as Drivers of Ulcerative and Immune Checkpoint Inhibitor Induced Colitis

[iScience] Investigators showed that intra-epithelial CD8+ T cells were significantly more abundant in anti-PD-1 ± anti-CTLA-4-induced colitis compared to anti-CTLA-4-induced colitis and ulcerative colitis.

Prognostic and Immunological Roles of IL18RAP in Human Cancers

[Aging] The authors discovered that IL18 receptor accessory protein (IL18RAP) was related to the human tumor microenvironment and promotes various immune cells infiltration.

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