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YTHDF1 Shapes “Cold” Tumor and Inhibits CD8+ T Cells Infiltration and Function in Breast Cancer

[Experimental Cell Research] The downregulation of YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) promoted the expression of pro-inflammatory markers and improved the anti-cancer ability of immune cells in breast cancer.

Regulatory T Cells Require IL6 Receptor Alpha Signaling to Control Skeletal Muscle Function and Regeneration

[Cell Metabolism] Using exercise and sarcopenia models, mice lacking IL6Rα on T cells demonstrated deficits in regulatory T cells, their functional maturation, and a more pronounced decline in muscle mass.

Oncometabolite D-2-Hydroxyglutarate—Dependent Metabolic Reprogramming Induces Skeletal Muscle Atrophy during Cancer Cachexia

[Communications Biology] Based on the up-regulation of catabolism and down-regulation of anabolism, researchers showed genetic mutation-mediated metabolic reprogramming in the progression of cancer cachexia by screening for metabolites and investigating their direct effect on muscle atrophy.

Myeloid-Derived Growth Factor Suppresses VSMC Dedifferentiation and Attenuates Postinjury Neointimal Formation in Rats by Activating S1PR2 and Its Downstream Signaling

[Acta Pharmacologica Sinica] Researchers investigated the effect of myeloid-derived growth factor to postinjury neointimal formation and the underlying mechanisms. Rat carotid arteries balloon-injured model was established.

Piezo Channels in Stretch Effects on Developing Human Airway Smooth Muscle

[American Journal Of Physiology-Lung Cellular And Molecular Physiology] Using 18-22-week gestation human fetal airway smooth muscle as an in vitro model, the authors tested the hypothesis that mechanosensitive Piezo channels contributed to stretch effects.

LKB1 Delays Atherosclerosis by Inhibiting Phenotypic Transformation of Vascular Smooth Muscle Cells

[International Journal Of Cardiology] ApoE−/− mice with vascular smooth muscle cells-specific overexpression of liver kinase B1 (LKB1) were constructed by adeno-associated virus transfection technique, and then fed with high-fat diet for eight weeks.

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